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@inproceedings{700795,
author = {Chovanec, Josef and Dostálová, Zuzana and Bienertová Vašků, Julie and Vašků, Anna and Belkov, AtanasandIvan},
address = {London, UK},
booktitle = {International Journal of Gynecological Cancer},
edition = {Supp 3},
keywords = {Endometrial cancer; obesity; leptin; adiponectin; polymorphism},
language = {eng},
location = {London, UK},
pages = {780-780},
publisher = {Blackwell Publishing},
title = {Association of leptin and adiponectin polymorphisms with endometrial cancer},
year = {2006}
}
TY - JOUR
ID - 700795
AU - Chovanec, Josef - Dostálová, Zuzana - Bienertová Vašků, Julie - Vašků, Anna - Belkov, Atanas-Ivan
PY - 2006
TI - Association of leptin and adiponectin polymorphisms with endometrial cancer
PB - Blackwell Publishing
CY - London, UK
KW - Endometrial cancer
KW - obesity
KW - leptin
KW - adiponectin
KW - polymorphism
N2 - Adiponectin is a recently described protein secreted by adipocytes, whose circulating levels are reduced in conditions related to insulin resistance and hyperinsulinemia. Leptin is small peptide produced by adipocytes and is implicated in a great number of endocrine regulations, whose impairment might result in obesity. The aim of this study was to investigate possible associations of previously described polymorphisms within the leptin (LEP -2548 G/A) and adiponectin gene (T94G) and development of endometrial cancer. Methods: Peripherial blood samples obtained of 16 women with endometrial cancer and 14 healthy controls were evaluated for leptin -2548 G/A and adiponectin T94G polymorphisms. Results: We did not found any significant differences in genotype distributions and allelic frequencies of both examined polymorphims (LEP -2548 G/A: pg=0.13 and Adipo T94G: pg=0.75) in endometrial cancer cases and controls. The endometrial cancer cases differed significantly from the controls in baseline patients characteristics, such as weight (p= < 0.0001), height (p= < 0.0001), LDL cholesterol plasma level (p=0.02) and spontaneous abortion rate (p=0.0006). Conclusions: Our results do not clearly support the hypothesis for leptin and adiponectin polymorphisms involvement in ethiopathogenesis of endometrial cancer. However, as this was a preliminary study, the number of cases in both cohorts might not be sufficient for finding a significant association.
ER -
CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ a Atanas-Ivan BELKOV. Association of leptin and adiponectin polymorphisms with endometrial cancer. In \textit{International Journal of Gynecological Cancer}. Supp 3. London, UK: Blackwell Publishing. s.~780-780. 2006.
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