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@article{705142,
author = {Vaňhara, Petr and Šmarda, Jan},
article_number = {4},
keywords = {AP-1; Jun; cancer; apoptosis; cell cycle; differentiation},
language = {eng},
issn = {1214-0287},
journal = {Journal of Applied Biomedicine},
title = {Jun: the master regulator in healthy and cancer cells},
volume = {4},
year = {2006}
}
TY - JOUR
ID - 705142
AU - Vaňhara, Petr - Šmarda, Jan
PY - 2006
TI - Jun: the master regulator in healthy and cancer cells
JF - Journal of Applied Biomedicine
VL - 4
IS - 4
SP - 163-170
EP - 163-170
SN - 12140287
KW - AP-1
KW - Jun
KW - cancer
KW - apoptosis
KW - cell cycle
KW - differentiation
N2 - Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells.
ER -
VAŇHARA, Petr a Jan ŠMARDA. Jun: the master regulator in healthy and cancer cells. \textit{Journal of Applied Biomedicine}. roč.~4, č.~4, s.~163-170. ISSN~1214-0287. 2006.
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