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Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated ...

ŠPINAR, Jindřich, Ondřej LUDKA, Ladislav DUŠEK, Dorota SOBOTOVÁ a Lenka ŠPINAROVÁ. Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemodialysis. Kidney Blood Press res, 2007, roč. 30, č. 5, s. 347-357. ISSN 1420-4096.
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Základní údaje
Originální název Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemodialysis.
Název česky Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemodialysis.
Autoři ŠPINAR, Jindřich (203 Česká republika, garant), Ondřej LUDKA (203 Česká republika), Ladislav DUŠEK (203 Česká republika), Dorota SOBOTOVÁ (203 Česká republika) a Lenka ŠPINAROVÁ (203 Česká republika).
Vydání Kidney Blood Press res, 2007, 1420-4096.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Cardiac and Cardiovascular systems
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.092
Kód RIV RIV/00216224:14110/07:00032953
Organizační jednotka Lékařská fakulta
UT WoS 000249306000012
Klíčová slova anglicky neurohumoral activity; heart failure; end-stage renal disease; hemodialysis
Štítky end-stage renal disease, Heart failure, hemodialysis, neurohumoral activity
Změnil Změnil: prof. RNDr. Ladislav Dušek, Ph.D., učo 670. Změněno: 1. 4. 2010 09:19.
Anotace
Background: Chronic renal failure treated by regular hemodialysis is frequently accompanied by chronic heart failure; the mortality of both is high. Aim: To evaluate the role of markers of neurohumoral activation for the prognosis of patients treated with regular dialysis. Patients: 99 patients with end-stage renal disease were followed up for 3 years. Methods: Clinical evaluation, echocardiography, biochemistry including NT-proBNP and big endothelin (Big-ET). Results: The incidence of heart failure was 97% and the 3-year mortality was 50%. The sensitivity of NT-proBNP and Big-ET level for the prediction of death was 0.712 and 0.824, respectively, and specificity 0.642 and 0.695, respectively. The cutoff points were NT-proBNP 6 2,000 pg/ml and Big-ET >= 1.55 pmol/l. Neither NT-proBNP nor Big-ET could be incorporated in the multivariate model for overall survival, which means that although both parameters significantly influenced overall survival as single risk factors, they were not effective in competition with the other significant predictors. Conclusion: Overall survival seems to be influenced namely by age, hemoglobin, left atrium diameter or pulmonary congestion class on chest X-ray, while probability of early risk was associated with Big-ET, history of diabetes mellitus, C-reactive protein, uric acid and hemoglobin. The only intersection of the models is hemoglobin as a thoroughly significant predictor. Copyright (c) 2007 S. Karger AG, Basel.
Anotace česky
Background: Chronic renal failure treated by regular hemodialysis is frequently accompanied by chronic heart failure; the mortality of both is high. Aim: To evaluate the role of markers of neurohumoral activation for the prognosis of patients treated with regular dialysis. Patients: 99 patients with end-stage renal disease were followed up for 3 years. Methods: Clinical evaluation, echocardiography, biochemistry including NT-proBNP and big endothelin (Big-ET). Results: The incidence of heart failure was 97% and the 3-year mortality was 50%. The sensitivity of NT-proBNP and Big-ET level for the prediction of death was 0.712 and 0.824, respectively, and specificity 0.642 and 0.695, respectively. The cutoff points were NT-proBNP 6 2,000 pg/ml and Big-ET >= 1.55 pmol/l. Neither NT-proBNP nor Big-ET could be incorporated in the multivariate model for overall survival, which means that although both parameters significantly influenced overall survival as single risk factors, they were not effective in competition with the other significant predictors. Conclusion: Overall survival seems to be influenced namely by age, hemoglobin, left atrium diameter or pulmonary congestion class on chest X-ray, while probability of early risk was associated with Big-ET, history of diabetes mellitus, C-reactive protein, uric acid and hemoglobin. The only intersection of the models is hemoglobin as a thoroughly significant predictor. Copyright (c) 2007 S. Karger AG, Basel.
Návaznosti
MSM0021622402, záměrNázev: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumné záměry
VytisknoutZobrazeno: 18. 4. 2019 14:51

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