2008
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
KAŇKOVÁ, Kateřina; Marta KALOUSOVA; Miluše HERTLOVÁ; Darja KRUSOVÁ; Jindřich OLŠOVSKÝ et al.Základní údaje
Originální název
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
Název česky
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
Autoři
Vydání
Arch Physiol Biochem, Informa Healthcare, 2008, 1381-3455
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30202 Endocrinology and metabolism
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 0.841 v roce 2000
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/08:00024150
Organizační jednotka
Lékařská fakulta
Klíčová slova anglicky
diabetes mellitus; soluble RAGE; AGEs; diabetic nephropathy; glomerular filtration rate
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 9. 4. 2008 19:05, prof. MUDr. Kateřina Kaňková, Ph.D.
V originále
Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P>0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs
Česky
Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P>0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs
Návaznosti
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