Two Common Polymorphisms Within The Adiponectin Gene Are
Associated With Food Preferences In Extremely Obese Czech
Individuals

D 2008

Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Josef TOMANDL; Martin FOREJT; Anna VAŠKŮ et. al.

Základní údaje

Originální název

Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals

Název česky

Dva v populaci četné polymorfismy v genu pro adiponektin jsou asociovány s potravními preferencemi u české extrémně obézní populace

Autoři

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Josef TOMANDL; Martin FOREJT a Anna VAŠKŮ

Vydání

2008. vyd. Praha, 13th International SHR Symposium, od s. 85-85, 1 s. 2008

Nakladatel

Institute for Clinical and Experimental Physiology, Prague

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

adiponectin; polymorphism; gene; obesity; food preferences

Štítky

adiponectin, food preferences, gene, obesity, polymorphism

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 6. 2008 22:49, prof. MUDr. Julie Vašků, Ph.D.

Anotace

ORIG CZ

V originále

Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences.

Česky

Získaná data naznačují silnou asociaci polymorfismů 45 T/G a 94 T/G v exonu 2 genu pro adiponektin s potravními preferencemi extrémně obézní české populace.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Josef TOMANDL; Martin FOREJT a Anna VAŠKŮ. Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals. In 13th International SHR Symposium. 2008. vyd. Praha: Institute for Clinical and Experimental Physiology, Prague, 2008, s. 85-85.

@inproceedings{770181,
   author = {Bienertová Vašků, Julie and Bienert, Petr and Tomandl, Josef and Forejt, Martin and Vašků, Anna},
   address = {Praha},
   booktitle = {13th International SHR Symposium},
   edition = {2008},
   keywords = {adiponectin; polymorphism; gene; obesity; food preferences},
   language = {eng},
   location = {Praha},
   pages = {85-85},
   publisher = {Institute for Clinical and Experimental Physiology, Prague},
   title = {Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals},
   year = {2008}
}

TY  - CONF
ID  - 770181
AU  - Bienertová Vašků, Julie - Bienert, Petr - Tomandl, Josef - Forejt, Martin - Vašků, Anna
PY  - 2008
TI  - Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals
PB  - Institute for Clinical and Experimental Physiology, Prague
CY  - Praha
KW  - adiponectin
KW  - polymorphism
KW  - gene
KW  - obesity
KW  - food preferences
N2  - Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences.
ER  -

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Josef TOMANDL; Martin FOREJT a Anna VAŠKŮ. Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals. In \textit{13th International SHR Symposium}. 2008. vyd. Praha: Institute for Clinical and Experimental Physiology, Prague, 2008, s.~85-85.

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