JANÍKOVÁ, Andrea, Karol BOLČÁK, Tomáš PAVLÍK, Jiří MAYER a Zdeněk KRÁL. Value of [F-18]fluorodeoxyglucose positron emission tomography in the management of follicular lymphoma: The end of a dilemma? CLINICAL LYMPHOMA & MYELOMA, 2008, roč. 8, č. 5, s. 287-293. ISSN 1557-9190.
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Základní údaje
Originální název Value of [F-18]fluorodeoxyglucose positron emission tomography in the management of follicular lymphoma: The end of a dilemma?
Název česky Význam FDG PET v léčbě folikulárního lymfomu. Konec dilematu?
Název anglicky Value of [F-18]fluorodeoxyglucose positron emission tomography in the management of follicular lymphoma: The end of a dilemma?
Autoři JANÍKOVÁ, Andrea (203 Česká republika, garant), Karol BOLČÁK (203 Česká republika), Tomáš PAVLÍK (203 Česká republika), Jiří MAYER (203 Česká republika) a Zdeněk KRÁL (203 Česká republika).
Vydání CLINICAL LYMPHOMA & MYELOMA, 2008, 1557-9190.
Další údaje
Originální jazyk čeština
Typ výsledku Článek v odborném periodiku
Obor 30200 3.2 Clinical medicine
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.596
Kód RIV RIV/00216224:14110/08:00034559
Organizační jednotka Lékařská fakulta
UT WoS 000260006700004
Klíčová slova česky nehodgkinský lymfom; přesná diagnostika; F-18-FDG; klasifikace; PET; transplantace
Klíčová slova anglicky NON-HODGKINS-LYMPHOMA; DIAGNOSTIC-ACCURACY; RESPONSE CRITERIA; WHOLE-BODY; PET; TRANSPLANTATION; CLASSIFICATION; F-18-FDG; INDOLENT; THERAPY
Štítky CLASSIFICATION, DIAGNOSTIC-ACCURACY, F-18-FDG, INDOLENT, NON-HODGKINS-LYMPHOMA, PET, RESPONSE CRITERIA, THERAPY, TRANSPLANTATION, WHOLE-BODY
Příznaky Recenzováno
Změnil Změnil: RNDr. Tomáš Pavlík, Ph.D., učo 52483. Změněno: 1. 4. 2010 09:24.
Anotace
[F-18]Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a powerful tool for the imaging of various lymphomas. Despite its high FDG avidity, there is little data on PET in follicular lymphoma (FL). In this work, we present findings concerning PET at staging and posttreatment evaluation in FL. Patients and Methods: A total of 181 PET scans were evaluated in 117 patients with FL in a retrospective study. Positron emission tomography-based results were compared with conventional staging in 82 patients. Posttreatment PET evaluation was performed in 99 patients; there were comparable progression-free survivals of PET-positive and PET-negative patients. Results: Positron emission tomography showed more involvement than computed tomography (CT) with clinical examination in 41 of 82 patients (50%), less in 11 of 82 (13%); the same extension was found in 27 of 82 patients (33%), and 3 patients revealed discordant foci visible on PET only and lymphadenopathy without PET activity (P < .001). Including the results of trephine biopsy, PET finally upstaged FL in 15 of 82 patients (18%), which was projected in change of treatment strategy. There were 73 of 99 negative posttreatment PET scans; 54 of 73 PET-negative patients (74%) remain in complete remission (median follow-up, 27 months); 19 (26%) of them relapsed with median of 12 months. Fourteen of 20 (70%) PET-positive patients relapsed with a median of 4.5 months regardless of findings on CT and subsequent therapy. The difference in relapse rates between PET-positive and PET-negative patients is statistically significant (P < .001). Conclusion: Positron emission tomography at staging is able to substantially change treatment strategy in an important proportion of patients with FL. Persisting PET positivity after treatment predicts for a high risk of an early relapse and can identify patients with poor prognosis.
Anotace anglicky
[F-18]Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a powerful tool for the imaging of various lymphomas. Despite its high FDG avidity, there is little data on PET in follicular lymphoma (FL). In this work, we present findings concerning PET at staging and posttreatment evaluation in FL. Patients and Methods: A total of 181 PET scans were evaluated in 117 patients with FL in a retrospective study. Positron emission tomography-based results were compared with conventional staging in 82 patients. Posttreatment PET evaluation was performed in 99 patients; there were comparable progression-free survivals of PET-positive and PET-negative patients. Results: Positron emission tomography showed more involvement than computed tomography (CT) with clinical examination in 41 of 82 patients (50%), less in 11 of 82 (13%); the same extension was found in 27 of 82 patients (33%), and 3 patients revealed discordant foci visible on PET only and lymphadenopathy without PET activity (P < .001). Including the results of trephine biopsy, PET finally upstaged FL in 15 of 82 patients (18%), which was projected in change of treatment strategy. There were 73 of 99 negative posttreatment PET scans; 54 of 73 PET-negative patients (74%) remain in complete remission (median follow-up, 27 months); 19 (26%) of them relapsed with median of 12 months. Fourteen of 20 (70%) PET-positive patients relapsed with a median of 4.5 months regardless of findings on CT and subsequent therapy. The difference in relapse rates between PET-positive and PET-negative patients is statistically significant (P < .001). Conclusion: Positron emission tomography at staging is able to substantially change treatment strategy in an important proportion of patients with FL. Persisting PET positivity after treatment predicts for a high risk of an early relapse and can identify patients with poor prognosis.
Návaznosti
MSM0021622430, záměrNázev: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumné záměry
VytisknoutZobrazeno: 26. 10. 2020 09:15