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@article{837731,
author = {Nováková, Jana and Slabý, Ondřej and Vyzula, Rostislav and Michálek, Jaroslav},
article_location = {San Diego (USA)},
article_number = {1},
keywords = {MicroRNA; Glioblastoma;Pathogenesis;Apoptosis;Cell cycle},
language = {eng},
issn = {0006-291X},
journal = {Biochemical and Biophysical Research Communications},
title = {MicroRNA involvement in glioblastoma pathogenesis},
url = {http://www.sciencedirect.com/science/journal/0006291X},
volume = {386},
year = {2009}
}
TY - JOUR
ID - 837731
AU - Nováková, Jana - Slabý, Ondřej - Vyzula, Rostislav - Michálek, Jaroslav
PY - 2009
TI - MicroRNA involvement in glioblastoma pathogenesis
JF - Biochemical and Biophysical Research Communications
VL - 386
IS - 1
SP - 1-5
EP - 1-5
PB - Elsevier
SN - 0006291X
KW - MicroRNA
KW - Glioblastoma;Pathogenesis;Apoptosis;Cell cycle
UR - http://www.sciencedirect.com/science/journal/0006291X
N2 - MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
ER -
NOVÁKOVÁ, Jana, Ondřej SLABÝ, Rostislav VYZULA a Jaroslav MICHÁLEK. MicroRNA involvement in glioblastoma pathogenesis. \textit{Biochemical and Biophysical Research Communications}. San Diego (USA): Elsevier, roč.~386, č.~1, s.~1-5. ISSN~0006-291X. 2009.
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