Elevated Malondialdehyde Correlates with the Extent of Primary
Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

J 2009

Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

SALZMAN, Richard; Lukáš PÁCAL; Josef TOMANDL; Kateřina KAŇKOVÁ; Eva TOTHOVA et al.

Základní údaje

Originální název

Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

Název česky

Elevace malondialdehydu koreluje s rozsahem primárního tumoru a predikuje špatnou prognózu karcinomů orofaryngu

Autoři

SALZMAN, Richard; Lukáš PÁCAL; Josef TOMANDL ; Kateřina KAŇKOVÁ; Eva TOTHOVA; Břetislav GÁL a Rom KOSTŘICA

Vydání

Anticancer Research, Greece, INT INST ANTICANCER RESEARCH, 2009, 0250-7005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.428

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/09:00040101

Organizační jednotka

Lékařská fakulta

UT WoS

000271487400076

Klíčová slova anglicky

head and neck carcinoma prognosis oxidative stress malondialdehyde

Změněno: 6. 6. 2012 08:53, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

ORIG CZ

V originále

There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).

Česky

Cílem studie bylo zkoumat vztah MDA, markeru oxidativního stresu , a spinocelulárního karcinomu dutiny ústní a orofaryngu.

Návaznosti

NR9200, projekt VaV

Název: Dynamika oxidativního stresu během onkoterapie ve vztahu k prognóze u pacientů s karcinomy hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Dynamika oxidativního stresu během onkoterapie ve vztahu k prognóze u pacientů s karcinomy hlavy a krku

Citovat

SALZMAN, Richard; Lukáš PÁCAL; Josef TOMANDL; Kateřina KAŇKOVÁ; Eva TOTHOVA; Břetislav GÁL a Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. Anticancer Research. Greece: INT INST ANTICANCER RESEARCH, 2009, roč. 10/2009, č. 29, s. 4227-4231. ISSN 0250-7005.

@article{869081,
   author = {Salzman, Richard and Pácal, Lukáš and Tomandl, Josef and Kaňková, Kateřina and Tothova, Eva and Gál, Břetislav and Kostřica, Rom},
   article_location = {Greece},
   article_number = {29},
   keywords = {head and neck carcinoma prognosis oxidative stress malondialdehyde},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer},
   volume = {10/2009},
   year = {2009}
}

TY  - JOUR
ID  - 869081
AU  - Salzman, Richard - Pácal, Lukáš - Tomandl, Josef - Kaňková, Kateřina - Tothova, Eva - Gál, Břetislav - Kostřica, Rom
PY  - 2009
TI  - Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer
JF  - Anticancer Research
VL  - 10/2009
IS  - 29
SP  - 4227-4231
EP  - 4227-4231
PB  - INT INST ANTICANCER RESEARCH
SN  - 02507005
KW  - head and neck carcinoma prognosis oxidative stress malondialdehyde
N2  - There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).
ER  -

SALZMAN, Richard; Lukáš PÁCAL; Josef TOMANDL; Kateřina KAŇKOVÁ; Eva TOTHOVA; Břetislav GÁL a Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. \textit{Anticancer Research}. Greece: INT INST ANTICANCER RESEARCH, 2009, roč.~10/2009, č.~29, s.~4227-4231. ISSN~0250-7005.

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