Elevated Malondialdehyde Correlates with the Extent of Primary
Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

J 2009

Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

SALZMAN, Richard, Lukáš PÁCAL, Josef TOMANDL, Kateřina KAŇKOVÁ, Eva TOTHOVA et. al.

Základní údaje

Originální název

Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

Název česky

Elevace malondialdehydu koreluje s rozsahem primárního tumoru a predikuje špatnou prognózu karcinomů orofaryngu

Autoři

SALZMAN, Richard (703 Slovensko, garant), Lukáš PÁCAL (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Kateřina KAŇKOVÁ (203 Česká republika, domácí), Eva TOTHOVA (703 Slovensko), Břetislav GÁL (203 Česká republika, domácí) a Rom KOSTŘICA (203 Česká republika, domácí)

Vydání

Anticancer Research, Greece, INT INST ANTICANCER RESEARCH, 2009, 0250-7005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.428

Kód RIV

RIV/00216224:14110/09:00040101

Organizační jednotka

Lékařská fakulta

UT WoS

000271487400076

Klíčová slova anglicky

head and neck carcinoma prognosis oxidative stress malondialdehyde

Změněno: 6. 6. 2012 08:53, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

ORIG CZ

V originále

There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).

Česky

Cílem studie bylo zkoumat vztah MDA, markeru oxidativního stresu , a spinocelulárního karcinomu dutiny ústní a orofaryngu.

Návaznosti

NR9200, projekt VaV

Název: Dynamika oxidativního stresu během onkoterapie ve vztahu k prognóze u pacientů s karcinomy hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Dynamika oxidativního stresu během onkoterapie ve vztahu k prognóze u pacientů s karcinomy hlavy a krku

Citovat

SALZMAN, Richard, Lukáš PÁCAL, Josef TOMANDL, Kateřina KAŇKOVÁ, Eva TOTHOVA, Břetislav GÁL a Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. Anticancer Research. Greece: INT INST ANTICANCER RESEARCH, 2009, roč. 10/2009, č. 29, s. 4227-4231. ISSN 0250-7005.

@article{869081,
   author = {Salzman, Richard and Pácal, Lukáš and Tomandl, Josef and Kaňková, Kateřina and Tothova, Eva and Gál, Břetislav and Kostřica, Rom},
   article_location = {Greece},
   article_number = {29},
   keywords = {head and neck carcinoma prognosis oxidative stress malondialdehyde},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer},
   volume = {10/2009},
   year = {2009}
}

TY  - JOUR
ID  - 869081
AU  - Salzman, Richard - Pácal, Lukáš - Tomandl, Josef - Kaňková, Kateřina - Tothova, Eva - Gál, Břetislav - Kostřica, Rom
PY  - 2009
TI  - Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer
JF  - Anticancer Research
VL  - 10/2009
IS  - 29
SP  - 4227-4231
EP  - 4227-4231
PB  - INT INST ANTICANCER RESEARCH
SN  - 02507005
KW  - head and neck carcinoma prognosis oxidative stress malondialdehyde
N2  - There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).
ER  -

SALZMAN, Richard, Lukáš PÁCAL, Josef TOMANDL, Kateřina KAŇKOVÁ, Eva TOTHOVA, Břetislav GÁL a Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. \textit{Anticancer Research}. Greece: INT INST ANTICANCER RESEARCH, 2009, roč.~10/2009, č.~29, s.~4227-4231. ISSN~0250-7005.

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