Three novel polymorphisms in the promoter region of the TIMP 3
gene are not associated with proliferative diabetic retinopathy
in type 2 diabetes mellitus

J 2003

Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus

BERÁNEK, Michal; Kateřina KAŇKOVÁ; Svatava TSCHÖPLOVÁ; Petr KOLÁŘ; Jiří VÁCHA et al.

Základní údaje

Originální název

Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus

Název česky

Tři nově identifikované polymorfizmy v promotorové oblasti genu pro TIMP 3 nejsou asociovány s proliferativní diabetickou retinopatií

Autoři

BERÁNEK, Michal; Kateřina KAŇKOVÁ; Svatava TSCHÖPLOVÁ; Petr KOLÁŘ a Jiří VÁCHA

Vydání

Current Eye Research, The Netherlands, Swets & Zeitlinger, 2003, 0271-3683

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.113

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

UT WoS

000185227300004

Klíčová slova česky

extracelulární matrix; genetic polymorphism; DM 2 typu; proliferativní retinopatie; TIMP

Klíčová slova anglicky

extracellular matrix; genetic polymorphism; T2DM; proliferative retinopathy; TIMP

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 8. 2010 15:46, prof. MUDr. Petr Kolář, Ph.D.

Anotace

ORIG CZ

V originále

Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms (-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjects. Conclusions: Polymorphisms in the promoter region of the TIMP-3 gene were not associated with the PDR in the Caucasian T2DM patients.

Česky

Nezjistili jsme asociaci tri nove identifikovanych polymorfizmu v promotorove oblasti genu pro TIMP-3 (-899T/A, -915A/G a ĄV1296T/C) nejsou asociovany s proliferativni diabetickou retinopatii.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BERÁNEK, Michal; Kateřina KAŇKOVÁ; Svatava TSCHÖPLOVÁ; Petr KOLÁŘ a Jiří VÁCHA. Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus. Current Eye Research. The Netherlands: Swets & Zeitlinger, 2003, roč. 27/2003, č. 2, s. 91-93. ISSN 0271-3683.

@article{894367,
   author = {Beránek, Michal and Kaňková, Kateřina and Tschöplová, Svatava and Kolář, Petr and Vácha, Jiří},
   article_location = {The Netherlands},
   article_number = {2},
   keywords = {extracellular matrix; genetic polymorphism; T2DM; proliferative retinopathy; TIMP},
   language = {eng},
   issn = {0271-3683},
   journal = {Current Eye Research},
   title = {Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus},
   volume = {27/2003},
   year = {2003}
}

TY  - JOUR
ID  - 894367
AU  - Beránek, Michal - Kaňková, Kateřina - Tschöplová, Svatava - Kolář, Petr - Vácha, Jiří
PY  - 2003
TI  - Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus
JF  - Current Eye Research
VL  - 27/2003
IS  - 2
SP  - 91-93
EP  - 91-93
PB  - Swets & Zeitlinger
SN  - 02713683
KW  - extracellular matrix
KW  - genetic polymorphism
KW  - T2DM
KW  - proliferative retinopathy
KW  - TIMP
N2  - Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms (-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjects. Conclusions: Polymorphisms in the promoter region of the TIMP-3 gene were not associated with the PDR in the Caucasian T2DM patients.
ER  -

BERÁNEK, Michal; Kateřina KAŇKOVÁ; Svatava TSCHÖPLOVÁ; Petr KOLÁŘ a Jiří VÁCHA. Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus. \textit{Current Eye Research}. The Netherlands: Swets \&{} Zeitlinger, 2003, roč.~27/2003, č.~2, s.~91-93. ISSN~0271-3683.

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