Clinical correlations of miR-21 expression in colorectal cancer
patients and effects of its inhibition on DLD1 colon cancer
cells

J 2012

Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

FALTEJSKOVÁ, Petra; Andrej BEŠŠE; Sabina ŠEVČÍKOVÁ; Lenka KUBICZKOVÁ; Marek SVOBODA et. al.

Základní údaje

Originální název

Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

Autoři

FALTEJSKOVÁ, Petra ; Andrej BEŠŠE; Sabina ŠEVČÍKOVÁ; Lenka KUBICZKOVÁ; Marek SVOBODA; Jan ŠMARDA; Igor KISS; Rostislav VYZULA a Ondřej SLABÝ

Vydání

International Journal of Colorectal Disease, New York, Springer, 2012, 0179-1958

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.238

Kód RIV

RIV/00216224:14740/12:00057342

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1007/s00384-012-1461-3

UT WoS

000310088000002

Klíčová slova česky

miR-21; kolorektální karcinom; DLD-1; 5-FU; L-OHP; senzitivita; apoptóza; migrace

Klíčová slova anglicky

miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 4. 2013 23:01, Olga Křížová

Anotace

V originále

MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA301/09/1115, projekt VaV

Název: Úloha proteinů c-Myb a Cox-2 při tvorbě střevních nádorů

Investor: Grantová agentura ČR, Úloha proteinů c-Myb a Cox-2 při tvorbě střevních nádorů

Citovat

FALTEJSKOVÁ, Petra; Andrej BEŠŠE; Sabina ŠEVČÍKOVÁ; Lenka KUBICZKOVÁ; Marek SVOBODA; Jan ŠMARDA; Igor KISS; Rostislav VYZULA a Ondřej SLABÝ. Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells. International Journal of Colorectal Disease. New York: Springer, 2012, roč. 27, č. 11, s. 1401-1408. ISSN 0179-1958. Dostupné z: https://doi.org/10.1007/s00384-012-1461-3.

@article{979090,
   author = {Faltejsková, Petra and Bešše, Andrej and Ševčíková, Sabina and Kubiczková, Lenka and Svoboda, Marek and Šmarda, Jan and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {New York},
   article_number = {11},
   doi = {https://doi.org/10.1007/s00384-012-1461-3},
   keywords = {miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration},
   language = {eng},
   issn = {0179-1958},
   journal = {International Journal of Colorectal Disease},
   title = {Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells},
   url = {http://link.springer.com/article/10.1007%2Fs00384-012-1461-3},
   volume = {27},
   year = {2012}
}

TY  - JOUR
ID  - 979090
AU  - Faltejsková, Petra - Bešše, Andrej - Ševčíková, Sabina - Kubiczková, Lenka - Svoboda, Marek - Šmarda, Jan - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
JF  - International Journal of Colorectal Disease
VL  - 27
IS  - 11
SP  - 1401-1408
EP  - 1401-1408
PB  - Springer
SN  - 01791958
KW  - miR-21
KW  - colorectal cancer
KW  - DLD-1
KW  - 5-FU
KW  - SN38
KW  - L-OHP
KW  - sensitivity
KW  - apoptosis
KW  - migration
UR  - http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
L2  - http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
N2  - MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.
ER  -

FALTEJSKOVÁ, Petra; Andrej BEŠŠE; Sabina ŠEVČÍKOVÁ; Lenka KUBICZKOVÁ; Marek SVOBODA; Jan ŠMARDA; Igor KISS; Rostislav VYZULA a Ondřej SLABÝ. Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells. \textit{International Journal of Colorectal Disease}. New York: Springer, 2012, roč.~27, č.~11, s.~1401-1408. ISSN~0179-1958. Dostupné z: https://doi.org/10.1007/s00384-012-1461-3.

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