Cytomine works with the concept of "annotations" -- areas of interest in the image specified with geometric primitives (point, rectangle, circle, ...) or free-form curve, and attached information (e.g. classification of the tissue, tumor type etc.).

The integration of third-party analysis tools will require definition of a protocol for image annotation specification, service identification and image processing result retrieval.

The thesis will extend the tool with the capability to process an entire image, annotation, or a set of annotations with a remotely called service, which may involve extensive computation, and to display back its results.

The principal components of the work are:

• Required extensions of the user interface
• Definition of communication protocol with the remote service
• Implementation of an example remote service (performing a trivial task, e.g. computing a histogram of pixel intensities in the selected area)

The thesis will document thoroughly the process of integrating another remotely called service. This documentation will serve developers of such services so that they can concentrate on their developments, not having to deal with complexities of Cytomine internals.

A practical outcome of the thesis is also working installation of the extended system available to the users.