Thesis/Dissertation: Mgr. Dagmar Čížková, učo 51804: Diversity and evolution of two MHC class II genes in wild populations of a model species, the house mouse
Doctoral thesis
Diversity and evolution of two MHC class II genes in wild populations of a model species, the house mouse
Diverzita a evoluce dvou MHC genů třídy II v divokých populacích modelového druhu - myši domácí
Abstract
V této práci se věnujeme molekulárně-genetické charakterizaci dvou těsně vázaných genů MHC třídy II v divokých populacích myši domácí (Mus musculus). Srovnáváme signály selekce a míru diverzifikace mezi těmito geny a také mezi jejich ortology u dvou poddruhů myši domácí – M. m. domesticus a M. m. domesticus. Ukazujeme, že navzdory těsné vazbě, se oba geny liší ve studovaných parametrech jejich evoluce …more
Abstract
In this thesis we analyse molecular-genetic characteristics of two closely linked MHC class II genes in wild populations of the house mouse (Mus musculus). We compare signals of selection and patterns of diversification between these two genes and between their orthologs in two house mouse subspecies, Mus m. musculus and Mus m. domesticus. We show that despite the close linkage, the two genes show …more
22/9/2015 07:36, prof. Mgr. et Mgr. Josef Bryja, Ph.D., UČO 7775
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