MYMC0111p Molecular and Cellular Neurosciences - lecture

Faculty of Medicine
autumn 2025
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MUDr. Markéta Bébarová, Ph.D. (lecturer)
prof. Mgr. Petr Beneš, Ph.D. (lecturer)
Mgr. Dáša Bohačiaková, Ph.D. (lecturer)
Valentina Lacovich Strašil, PhD (lecturer)
doc. MUDr. Robert Roman, Ph.D. (lecturer)
Guaranteed by
doc. MUDr. Markéta Bébarová, Ph.D.
Department of Physiology – Theoretical Departments – Faculty of Medicine
Supplier department: First Department of Neurology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine (37,50 %), Department of Physiology – Theoretical Departments – Faculty of Medicine (12,50 %), Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine (25,00 %), Department of Experimental Biology – Biology Section – Faculty of Science (25,00 %)
Timetable
Thu 18. 9. 16:00–17:40 A20/207, Thu 2. 10. 16:00–17:40 A20/207, Thu 16. 10. 16:00–17:40 A20/207, Thu 30. 10. 16:00–17:40 A20/207, Thu 13. 11. 16:00–17:40 A20/207, Thu 4. 12. 16:00–17:40 A20/207, Thu 11. 12. 16:00–17:40 A20/207, Thu 18. 12. 16:00–17:40 A20/207
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
At the end of this course, the student will understand the principles of the development and organization of the nervous system and will be able to describe the basic molecular mechanisms crucial for the development and function of the nervous system.
Learning outcomes
Upon successful completion of the course, the student will:
- understand the mechanisms leading to neuronal death or dysfunction (proteinopathy)
- understand the role and structure of the blood-brain barrier and its disorders - understand the role of mutations and common population genetic variation in the development of diseases of the nervous system
- be able to characterize the basic abnormalities leading to the development of neurodegenerative, autoimmune, and other diseases of the nervous system, and the possibilities of regeneration and modification of neuroplasticity (e.g., in traumatic disabilities),
- orientation in the peculiarities of immunological protection of the CNS and related inflammatory disorders
Key topics
  • Biology of neurons and glia, their isolation, culture and analysis in vitro
  • Cellular electrophysiology of nervous tissue
  • Basic techniques for recording neuronal electrical activity at the cellular and tissue level
  • Development of the nervous system, differentiation of neurons and glial cells, regulation of gene expression.
  • Stem cell biology, cell culture methods
  • Organoids: biology and applications in neuroscience
  • Brain development - genetic aspects, processes regulating axon growth and navigation, synapse formation, neuronal motility.
  • Aging and death of neurons, possibilities of regeneration
  • Introduction to genetic epidemiology
  • Excursions to research laboratories
Study resources and literature
    not specified
  • SMITH, C. U. M. Elements of molecular neurobiology. 3rd ed. Chichester: John Wiley & Sons, 2002, xvi, 613. ISBN 0471560383. info
Approaches, practices, and methods used in teaching
Lecture + discussion Self-study of recommended literature
Method of verifying learning outcomes and course completion requirements
The course will end with a written test (single best answer) covering the content of the material covered. Credit will be awarded in case of a minimum 75% success rate.
Language of instruction
Czech
Further Comments
Study Materials
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2025/MYMC0111p