aVLKB091 Clinical Biochemistry

Faculty of Medicine
autumn 2018
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: k (colloquium).
Teacher(s)
MUDr. Dana Bučková, Ph.D. (lecturer)
MUDr. Zdeňka Čermáková, Ph.D. (lecturer)
doc. MUDr. Milan Dastych, CSc., MBA (lecturer)
MUDr. Milan Dastych (lecturer)
MUDr. Miroslava Hlaváčová, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
MUDr. Ondřej Kyselák (lecturer)
prof. MUDr. Vladimír Soška, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Hana Vinohradská (lecturer)
Mgr. Radomíra Bednářová (assistant)
doc. RNDr. Jiří Dostál, CSc. (assistant)
Mgr. Miroslav Fiala (assistant)
Mgr. et Mgr. Zuzana Handlová (assistant)
Lenka Nerudová (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Ladislav Václavík, Ph.D. (assistant)
Supervisor
doc. MUDr. Milan Dastych, CSc., MBA
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: Lenka Nerudová
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable
Mon 1. 10. to Fri 7. 12. Tue 13:00–15:30 A11/327; and Tue 11. 12. 13:00–14:00 A11/327
Prerequisites
aVLFA0822c Pharmacology II -pr. || VLFA0722c Pharmacology IIp
Completion of subject aVLFA0822p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
Fields of study the course is directly associated with
Course objectives
After this course the participant should be able to: - choose biochemical tests suitable for diagnostics of diseases - know the basic problems of common biochemical diagnostic tests - know how to collect biological material and how to treat it to prevent false results - to assess reliability of laboratory results.
Learning outcomes
Student will be able to:
purposefully indicate laboratory biochemical tests
correctly interpret laboratory results
evaluate laboratory tests with regard to their sensitivity and specificity
use knowledge of the uncertainty of the evaluated parameter
to focus on possible pre-analytical influences and interferences
Syllabus
  • Analytical sources of variation, accuracy and precision. Diagnostic accuracy, sensitivity, specificity, and efficiency of diagnostic tests. Reference ranges, decision values. Collection and processing of specimens, special requirements, general safety rules.
  • Assessment and monitoring of nutritional status. Blood plasma proteins. Acute-phase reactants. Principles of nutritional support, enteral and parenteral nutrition. Dietary constituents providing a sufficient energy intake.
  • Energy output, nitrogen balance. Indications for nutritional support. Oxygen, transport and metabolism, tissue hypoxia.
  • Disorders of lipid and lipoprotein metabolism.
  • Ischemic heart disease, congestive cardiac failure. Potassium and magnesium homeostasis.
  • Iron and essential microelements metabolism.
  • Disturbances of water and sodium balance. Plasma and urine osmolality. Plasma electrolytes in acid-base disorders.
  • Assessment of acid-base balance. Investigating an acid-base status, indications for blood acid-base and oxygen measurements, interpretation of results.
  • Laboratory evaluation of kidney function. Biochemical monitoring of acute and chronic renal failure, and of patients receiving haemodialysis. Urine sediment.
  • Investigation of liver and biliary tract diseases. Signs of the liver injury, differentiating of hyperbilirubinaemias, syndrome of biliary obstruction.
  • Clinical biochemistry of the GIT. Gastric acid secretion, maldigestion and malabsorption, assessment of pancreatic function.
  • Disorders of saccharide metabolism, diabetes mellitus.
  • Calcium and phosphate metabolism. Biochemical markers of bone metabolism (in the assessment of osteoporosis).
  • Uric acid, hyperuricaemia. Renal tract stones.
  • Laboratory assessment of thyroid and adrenal functions.
  • Tumour markers. Biological causes of variation of test results, effects of drugs on chemical tests.
Literature
    recommended literature
  • Tietz fundamentals of clinical chemistry. Edited by Carl A. Burtis - Edward R. Ashwood - David E. Bruns - Barbara G. Sawye. 6th ed. St. Louis, Mo.: Saunders/Elsevier, 2008. xx, 952. ISBN 9780721638652. info
  • Clinical chemistry : techniques, principles, correlations. Edited by Michael L. Bishop - Edward P. Fody - Larry E. Schoeff. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2010. xx, 732. ISBN 9780781790451. info
Teaching methods
lectures, audio-visual study materials, pp-presentations,commentated videos, interactive inputs
Assessment methods
written test, the test consists of 40 questions,25 correct answers is needed to pass; colloquium
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Information on course enrolment limitations: kromě studentů LF maximálně 3 studenti MU v jednom běhu
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2017.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2018/aVLKB091