VSBC0221p Biochemistry I - lecture

Faculty of Medicine
Spring 2008
Extent and Intensity
2/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
doc. MUDr. Jaromír Sláma, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
Mgr. Milena Matejovičová, Ph.D. (seminar tutor)
Ing. Jitka Melounová, Ph.D. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
Mgr. Jan Alán (assistant)
RNDr. Hana Bochořáková (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
Mgr. Martin Klepárník, Ph.D. (assistant)
Lenka Nerudová (assistant)
MUDr. Hana Nováková, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
VSBC0221p/01: Wed 9:30–11:20 P31 Posluchárna A. I. Bláhy; and Wed 28. 5. 9:30–11:20 P51 Posluchárna V. Čermáka
VSBC0221p/02: Wed 7:30–9:20 P51 Posluchárna V. Čermáka; and Wed 28. 5. 9:30–11:20 P51 Posluchárna V. Čermáka
VSBC0221p/03: Wed 9:30–11:20 P31 Posluchárna A. I. Bláhy; and Wed 28. 5. 9:30–11:20 P51 Posluchárna V. Čermáka
Prerequisites (in Czech)
VSLC011s Med.Chem.-seminar && VSLC011c Medical Chemistry -p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
there are 8 fields of study the course is directly associated with, display
Syllabus
  • Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Enzyme cofactors, review of structures and functions. Mechanisms of enzyme action. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity, the conditions used. Factors affecting catalytic activity of enzymes, types of enzyme inhibition. Metabolism: basic concepts and design. Biological oxidations, generation of high-energy compounds. Saccharide metabolism: the glycolytic pathway and aerobic decarboxylation of pyruvate. Gluconeogenesis. Glycogen biosynthesis and breakdown. The pentose phosphate pathway. The glucuronate pathway. Interconversions of monosaccharides and of their derivatives. Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle. Metabolic breakdown of individual amino acids. Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols. Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids. Interrelationships among the major pathways involved in energy metabolism. The citric acid cycle. Synthesis of haem. Mitochondria. Oxidative phosphorylation - mitochondrial electron transport chain, synthesis of ATP. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Chromatin, DNA replication. DNA transcription. Regulation of gene expression. Protein synthesis and post-translational processing.
Literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny (I. a II. díl). 1st ed. Praha: Karolinum, 2004, 561 pp. ISBN 80-246-0851-0. info
  • MURRAY, R.K. and D.K. GRANNER. Harperova biochemie. 3. v ČR. Jinočany: H & H, 2001, 872 pp. ISBN 80-7319-003-6. info
  • HOLEČEK, Milan. Regulace metabolizmu cukrů, tuků, bílkovin a aminokyselin. 1st ed. Praha: Grada Publishing, 2006, 286 pp. učebnice. ISBN 80-247-1562-7. info
  • Biochemistry :a concise text for medical students. Edited by D. K. Apps. 5th ed. London: Bailliere Tindall, 1992, vii, 448 s. ISBN 0-7020-1444-3. info
  • MURRAY, R. K., D. K. GRANNER and V. W. RODWELL. Harper's Illustrated Biochemistry. 27th ed. New York: Lange, 2006, 692 pp. textbook. ISBN 0-07-147885-x. info
  • CHAMPE, P. C., R. A. HARVEY and D. R. FERRIER. Lippincott's Illustrated Reviews: Biochemistry. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2005, 534 pp. textbook. ISBN 0-7817-2265-9. info
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on completion of the course: zkoušku lze konat až po absolvování zkoušky z Lékařské chemie
The course is taught annually.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Lékařské chemie.
Listed among pre-requisites of other courses
Teacher's information
http://www.med.muni.cz/toCP1250.cs/biochem/vyuka.html
The course is also listed under the following terms Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Autumn 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016.
  • Enrolment Statistics (Spring 2008, recent)
  • Permalink: https://is.muni.cz/course/med/spring2008/VSBC0221p