BVBC0221p Biochemistry - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught online.
Mgr. Marie Tomandlová, Ph.D. (lecturer)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Monika Šudáková (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
Mgr. Marie Tomandlová, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Wed 3. 3. 8:00–9:50 A20/207, Wed 10. 3. 8:00–9:50 A20/207, Wed 17. 3. 8:00–9:50 A20/207, Wed 24. 3. 8:00–9:50 A20/207, Wed 31. 3. 8:00–9:50 A20/207, Wed 7. 4. 8:00–9:50 A20/207, Wed 14. 4. 8:00–9:50 A20/207, Wed 21. 4. 8:00–9:50 A20/207, Wed 28. 4. 8:00–9:50 A20/207, Wed 5. 5. 8:00–9:50 A20/207, Wed 12. 5. 8:00–9:50 A20/207, Wed 19. 5. 8:00–9:50 A20/207, Wed 26. 5. 8:00–9:50 A20/207, Wed 2. 6. 8:00–9:50 A20/207, Wed 9. 6. 8:00–9:50 A20/207
Prerequisites (in Czech)
BVLC011s Med.Chem.-seminar && BVLC011c Medical Chemistry -p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.
Learning outcomes
In the end of the course will students:
- understand the properties and function of enzymes
- describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships
- understand the principles of energy production, utilization and deposition at the cellular level
- explain the function of cell membranes and the transport processes on the membrane
- describe protein synthesis, understand the relationship between protein structure and function
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance
  • Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity. Factors affecting catalytic aktivity of enzymes, types of enzyme inhibition.
  • Enzyme cofactors, review of structures and functions. Metabolism - basic concepts and design. Biological oxidations, generation of high-energy compounds.
  • Interrelationships among the major pathways involved in energy metabolism. The citric acid cycle. Oxidative phosphorylation.
  • Saccharide metabolism: the glycolytic pathway.
  • Gluconeogenesis. Glycogen biosynthesis and breakdown.
  • The pentose phosphate pathway.Interconversions of monosaccharides and of their derivatives.
  • Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle.
  • Metabolic breakdown of individual amino acids.
  • Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols.
  • Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids.
  • Metabolism of haem. Haemoglobin, myoglobin. Hemoglobinopathy.
  • Biosynthesis and catabolism of purine and pyrimidine nucleotides. DNA replication.
  • DNA transcription. Regulation of gene expression.
  • Protein synthesis and post-translational processing.
    recommended literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny, I. a II. díl. Druhé vydání. Praha: Karolinum, 2009. 546 pp. ISBN 978-80-246-1414-4. info
  • MATOUŠ, Bohuslav. Základy lékařské chemie a biochemie. 1. vyd. Praha: Galén, 2010. xv, 540. ISBN 9788072627028. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012. 498 pp. ISBN 978-80-247-2977-0. info
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017. viii, 567. ISBN 9781496363541. info
Teaching methods
Teaching form are lectures.
Assessment methods
Oral examination.
Language of instruction
Follow-Up Courses
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů BVLC011p a BVBC0221s.
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020.
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