LF:ZLFA0621p Pharmacology I - lect.

ZLFA0621p Pharmacology I - lecture

Faculty of Medicine
Spring 2013

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: -.

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Timetable

Tue 13:50–15:30 B11/114

Prerequisites (in Czech)

ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

Dentistry (eng.) (programme LF, M-ZL)
Dentistry (programme LF, M-ZL)

Course objectives

At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.

Syllabus

LECTURES
Spring semester 2013 (Friday 1:30-3:10 p.m.)
1^st week, February, 22
The scope and historical development of modern pharmacology. Basic pharmacological terms, definitions. Drug regulation. Types of pharmacotherapy and drug effects.
2^nd week, March, 1
Innovative and generic products. Biosimilars. Orphan drugs. Drug-life cycle.
3^rd week, March, 8
Drug delivery approaches, routes of administration, prolonged release preparations.
4^th week, March, 15
Adverse drug effects. Physiological and pathological factors influencing drug effects. Importance of the pharmacological anamnesis,monitoring of drug pharmacotherapy, risk of pharmacotherapy.
5^th week, March, 22
Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration.
6^th week, March, 29
Mechanisms of drug action, non-specific, specific. Receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors.
7^th week, April, 5
Drug interactions. Assessment of the seriousness of drug interactions.
8^th week, April, 12
Pharmacogenetic, pharmacogenomic and their clinical implication.
9^th week, April, 19
Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiarities. Pharmacotherapy in neonates.
10^th week,April, 26
Specificities of pharmacotherapy in the elderly.
11^th week, May, 3
Pre-clinical and clinical drug development. Drug registration guidance. Regulation and guidelines for "Good Clinical Practice".
12^th week, May, 10
Principles of pharmacovigilance, duties of physicians and pharmaceutical companies. The management of poisoning.
13^th week, May, 17
The management of poisoning.
14^th week, May, 24
Basic principles of pharmacoeconomics, types of pharmacoeconomic analyses and their relevant use in clinical practice.
15^th week, May, 31:
Immunomodulant and systemic enzyme pharmacotherapy.

Literature

required literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
https://is.muni.cz/auth/el/1411/jaro2009/VLFA0621c/um/Practicals_in_Pharmacology_ENGL.pdf?fakulta=1411;obdobi=4504;kod=VLFA0621c
http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html

recommended literature

Rang & Dale's pharmacology 7th Edition :with student consult online access. Edited by H. P. Rang. : Churchill Livingstone, 2012
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 1. vyd. Praha: Grada, 2007, 379 s. ISBN 9788024713564. info

Teaching methods

According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.

Assessment methods

There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

Enrolment Statistics (Spring 2013, recent)
Permalink: https://is.muni.cz/course/med/spring2013/ZLFA0621p

LF:ZLFA0621p Pharmacology I - lect. - Course Information

ZLFA0621p Pharmacology I - lecture

Other applications