ZLFA0621p Pharmacology I - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
1/0/0. 1 credit(s). Type of Completion: z (credit).
Taught in person.
Teacher(s)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Jana Kubátová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
PharmDr. Mária Hricková (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
PharmDr. Adéla Bártová (assistant)
Renata Bláblová (assistant)
PharmDr. Tomáš Hammer (assistant)
MUDr. Alena Máchalová, Ph.D. (assistant)
Mgr. Marta Vyoralová (assistant)
doc. RNDr. Ladislava Bartošová, Ph.D. (alternate examiner)
MUDr. Jana Pistovčáková, Ph.D. (alternate examiner)
Mgr. Barbora Říhová, Ph.D. (alternate examiner)
PharmDr. Lenka Součková, Ph.D. (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Fri 23. 2. 14:00–15:40 B11/234, Fri 1. 3. 14:00–15:40 B11/234, Fri 8. 3. 14:00–15:40 B11/234, Fri 15. 3. 14:00–15:40 B11/234, Fri 22. 3. 14:00–15:40 B11/234, Fri 5. 4. 14:00–15:40 B11/234, Fri 12. 4. 14:00–15:40 B11/234
Prerequisites
ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
At the end of the course, the student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology, clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, the status of the organism (differences in paediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance. The student will know a basic pharmacological profile of selected drug groups.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Learning outcomes
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Syllabus

  • Schedule of lectures

    Spring semester 2024

  • 23.2.2024
  • 1. INTRODUCTION TO THE STUDY OF PHARMACOLOGY, DRUG'S LIFE CYCLE
  • Lecture content: Definitions and basic pharmacologic terminology, pharmacological subdisciplines. Classification of drugs and drug's names.Types of pharmacotherapy, rational pharmacotherapy. Legislative related to the drugs use. Drug safety, types of doses. Drug's life cycle.
  • 1.3.2024
  • 2. BASIC OF PHARMACOKINETICS AND PHARMACODYNAMICS
  • Lecture content: Obecné zákonitosti pohybu léčiva v organismu. Absorpce, distribuce, biotransformace, vylučování. Základní farmakokinetické parametry. Specifické a nespecifické mechanismy účinků léčiv. Receptorová teorie.
  • 8.3.2024
  • 3. SAFETY OF DRUGS, FACTORS INFLUENCING DRUG'S EFFECT
  • Lecture content: Classification and characteristic of drug's adverse effects. Pharmacovigilance and drugs' safety information databases. Classification and overview of factors influencing drug's effect. Basics of pharmacogenetics, Classification of drug interactions. Pharmacotherapy in children, pregnancy, breast-feeding and in elders.
  • 15.3.2024
  • 4. ANTIDIABETICS, INSULINS
  • Lecture content: Inzulins and antidiabetics – classification, therapeutic use and basic pharmacological profile.
  • 22.3.2024
  • 5. PHARMACOLOGICALLY USED HORMONES
  • Lecture content: Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens – basic pharmacological profile. Hormonal contraceptives. Drugs used in thyroid gland dysfunction. Drugs influencing bone metabolism. Overview of glucocrticoids and their therapeutic use.
  • 29.3.2024
  • 6. PUBLIC HOLIDAY/INTRODUCTION TO THE PHARMACOLOGY OF ANS
  • Lecture content: Introduction to the pharmacology of sympathetic and parasympathetic nervous system - neurotransmission, receptors. Overview of sympathotropic and cholinotropic drugs. Record of lecture will be available in the IS.
  • 5.4.2024
  • 7. PHARMACOLOGY OF GIT AND HISTAMINE
  • Lecture content: Drugs influencing GIT – laxatives, antidiarrhoics, antiemetics, antiulcer agents. Classification and overview of H1-antihistamines.
  • 12.4.2024
  • 8. INTRODUCTION OF BIOLOGICAL THERAPY
  • Lecture content: Principles of biological therapy, examples of drugs and their use, pharmacokinetics of monoclonal antibodies and their specific adverse effects.
Literature
    recommended literature
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN, Emma S. J. ROBINSON and James FULLERTON. Rang & Dale's pharmacology / James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEvan, Emma Robinson, James Fullerton. Tenth edition. London: Elsevier, 2024, xvii, 850. ISBN 9780323873963. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy
  • NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010, 96 pp. ISSN 1801-6103. URL info
  • Základy speciální receptury léčivých přípravků, Juřica a kol., 2014, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • Soubor kazuistik z farmakologie, Zendulka a kol., 2016 http://elportal.cz/publikace/kazuistiky-farmakologie
    not specified
  • ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
Teaching methods
Teaching is in the form of lectures, where students can raise questions on the topic directly to the lecturer. A video recording is made of the lecture, which is available to students for self-study. In addition, students have the possibility to raise questions to the lecturer of each topic using the discussion forum in IS.
Assessment methods
Students progress to the follow-up course in the following semester without the obligation to test their knowledge in this semester.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Teacher's information
Information for students studying in Czech:

In the spring semester, the course is completed with credit. After receiving credit, students move on to continuing education in the next semester without having to test their knowledge in that semester. Further assessment conditions in the follow-up course are published for students under the course code ZLFA0621c.

The lecture recording and discussion thread for each lecture is embedded within the interactive syllabus in IS.

The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023.
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