ZLFA0621p Pharmacology I - lecture

Faculty of Medicine
spring 2020
Extent and Intensity
1/0/0. 0 credit(s). Recommended Type of Completion: z (credit). Other types of completion: -.
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
Mgr. Jana Kubátová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
Mgr. Kristýna Nosková, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
MUDr. Jana Unar Vinklerová, Ph.D., MBA (lecturer)
prof. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
PharmDr. Eva Klásková (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Fri 27. 3. 14:00–15:40 B11/234, Fri 17. 4. 14:00–15:40 B11/234, Wed 6. 5. 16:00–17:40 B11/114, Fri 29. 5. 14:00–15:40 B11/234
Prerequisites (in Czech)
ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Learning outcomes
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Syllabus

  • LECTURES

  • Spring semester 2020

  • 1st lecture
  • Historical aspects of pharmacology. Pharmacology — definitions, terminology, subspecializations. The active substance, pharmacon - drug. Effective pharmacotherapy.
  • 2nd lecture
  • Mechanisms of drug action, non-specific, specific. Receptor and binding sites subtypes, autoreceptors, heteroreceptors, their function.
  • 3rd lecture
  • Basic principles of Pharmacokinetics. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration.
  • 4th lecture
  • Adverse drug effects. Physiological and pathological factors influencing drug effects. Influence of concomitant diseases on drug effect, polypragmasia.
  • 5th lecture
  • Specificities of pharmacotherapy in pediatric population and in elderly.
  • 6th lecture
  • General principles of poisoning management. Specific antidotes in poisoning therapy.
  • 7th lecture
  • Types of addiction, therapy of substance abuse.
  • 8th lecture
  • Drug interactions at different levels. Assessment of their seriousness.
Literature
    required literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Online. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. [citováno 2024-04-24] info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
    recommended literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. Online. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. [citováno 2024-04-24] info
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • WHALEN, Karen. Pharmacology. Online. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. [citováno 2024-04-24] info
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
    not specified
  • Pharmaceutical practice. Online. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. [citováno 2024-04-24] info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). Online. ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. [citováno 2024-04-24] info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. Online. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. [citováno 2024-04-24] info
Teaching methods
According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.
Assessment methods
There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (spring 2020, recent)
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