aZLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2016
Extent and Intensity
1/0. 3 credit(s). Type of Completion: zk (examination).
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
doc. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
doc. Yuh-Man Wadeley, Doctor of Philosophy (lecturer)
Jana Růžičková (assistant)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology - Theoretical Departments - Faculty of Medicine
Contact Person: Mgr. Kateřina Cetkovská, Ph.D.
Supplier department: Department of Biology - Theoretical Departments - Faculty of Medicine
Wed 13:00–13:50 B11/234
( aZLBI0121c Biology I - pract. || ZLBI0121c Biology I - pract. ) && ( aZC011 Handling chemical substances || ZC011 Handling chemical substances )
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisities for studying the course. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After completion of the course student: understands elementary cellular processes and processes taking place during development of a human body; comprehends the complexity of intercellular communication and mutual regulation of individual cells in a multicellular organism; is able to deduce and explain the difference between healthy and pathologically-working cell; is able to express basic coherence between malfunction in cellular processes and development of diseases, especially hereditary diseases, cancers or developmental defects; can explain and justify action of some therapeutics with emphasis on modern medicine. Student is also able to apply this knowledge and skills in other subject, especially physiology, pathophysiology and human genetics.
  • Week 1: 22.2. – 26.2. 2014
  • Growth factors and signal transduction in development and disease (Mgr. Pavel Krejčí, Ph.D.)
  • Week 2: 29.2. – 4.3.
  • Biology and use of stem cells in disease modelling and cell therapy (prof. Ing. Petr Dvořák, CSc.)
  • Week 3: 7.3. – 11.3.
  • Cell differentiation and tissue engineering (prof. Ing. Petr Dvořák, CSc.)
  • Week 4: 14.3. – 18.3.
  • Genome instability - from molecular mechanisms of damage and DNA repair to clinical implications (doc. Mgr. Lumír Krejčí, Ph.D)
  • Week 5: 21.3. – 25.3.
  • Introduction to cancer biology (Mgr. Stjepan Uldrijan, CSc.)
  • Week 6: 28.3. – 1.4.
  • Oncogenes and oncoviruses in cancer transformation (Mgr. Stjepan Uldrijan, CSc.)
  • Week 7: 4.4. – 8.4.
  • Tumour suppressor genes - implications for diagnostics and therapy (Mgr. Stjepan Uldrijan, CSc.)
  • Week 8: 11.4. – 15.4.
  • Paradigm of cancer stem cells (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 9: 18.4. – 22.4.
  • Molecular principle of genetically determined diseases (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 10: 25.4. – 29.4.
  • Objectives and strategies of molecular therapy (doc. MUDr. Iva Slaninová, Ph.D.)
  • Week 11: 2.5. – 6.5.
  • Genomics and other omics in current biomedicine (prof. MUDr. David Šmajs, Ph.D.)
  • Week 12: 9.5. – 13.5.
  • Human microbiome (prof. MUDr. David Šmajs, Ph.D.)
  • Week 13: 16.5. – 20.5.
  • Bioinformatics in medicine - from molecules to populations (Mgr. Vladimír Rotrekl, Ph.D.)
  • Week 14: 23.5. – 27.5.
  • substitution lecture
    required literature
  • Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009. 1 v. ISBN 9780815341307. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013. 1 online r. ISBN 9781118689028. info
    recommended literature
  • HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012. xxviii, 79. ISBN 9780321709783. info
  • LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008. xxxvii, 11. ISBN 9780716776017. info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Principles of genetics. 5th ed. Hoboken: John Wiley & Sons, Inc, 2009. xix, 823. ISBN 9780470388259. info
  • WEINBERG, Robert A. The biology of cancer. Second edition. London: Garland Science, 2013. xx, 876. ISBN 9780815345282. info
  • WOLPERT, Lewis. Principles of development. 2nd ed. Oxford: Oxford University Press, 2002. xxv, 542. ISBN 0198792913. info
    not specified
  • CAMPBELL, Neil A. Biology. Edited by Jane B. Reece. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005. xl, 1231. ISBN 080537146X. info
Teaching methods
Assessment methods
The subject is completed with a written examination test, based on knowledge of all topics from both semesters (lectures, practices). The test contains 94 questions with 1 correct answer. Negative marking is obtained for incorrect answers. For successful passing the exam, minimum 64 points out of 188 are needed.
Requirements for attendance at the exam: successful passing of the autumn semester’s lecture and seminar, and successfull completion of Biology-practices of both autumn and spring semester.
Students have to bring their valid ICIS card to prove their identity at the exam. For more information on the test see:
Lecture attendance is optional.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

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Teacher's information
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021.
  • Enrolment Statistics (Spring 2016, recent)
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