aFAFC2_14 Human Physiology and Pathophysiology II

Faculty of Pharmacy
Autumn 2025

The course is not taught in Autumn 2025

Extent and Intensity
2/2/0. 5 credit(s). Type of Completion: zk (examination).
Teacher(s)
MVDr. Jana Hložková, Ph.D. (lecturer)
MUDr. Tomáš Parák, Ph.D. (lecturer)
doc. MVDr. Pavel Suchý, Ph.D. (lecturer)
prof. MUDr. Jiří Vítovec, CSc. (lecturer)
MVDr. Jana Hložková, Ph.D. (seminar tutor)
MUDr. Tomáš Parák, Ph.D. (seminar tutor)
PharmDr. Lenka Paráková, Ph.D. (seminar tutor)
MVDr. Peter Scheer, Ph.D. (seminar tutor)
Guaranteed by
MUDr. Tomáš Parák, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Prerequisites (in Czech)
aFAFC1_14 Human Phys. and Pathophys. I
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
Human physiology is defined as a science of the functions of healthy organism at the level of cell, tissue, organ and organ systems. Pathophysiology is focused on etiopathogenesis - the mechanisms which lead from the primary cause via individual malfunctions to subsequent development of clinical symptoms of disease. Knowledge of these mechanisms serves to develop a suitable and efficient therapy and prevent resultant damage.
Learning outcomes
After completing the course, the student will be able to:
- describe the physiology and pathophysiology of the main organs
- recognize subjective and objective symptoms of diseases
- examine the main physiological functions
- interpret examination results
Key topics
1. Acute and chronic health failure. Cardiac asthma, pulmonary heart disease.
2. Gastrointestinal tract and its functions. Pathophysiology of liver and pancreas.
3. Respiratory system, its functions. Obstructive and degenerative pulmonary processes
4. Pulmonary hypertension syndrome. Pulmonary TBC. Respiratory
insufficiency.
5. Physiology of kidneys and lower urinary tract. Kidney failure.
6. Basic mechanisms of endocrine regulation, most common disorders. Diabetes mellitus,
complications.
7. Physiology of sex hormones and reproductive system.
8. Physiology of excitable tissue, excitement transmission.
9. CNS pathophysiology, pain, brain arterial network disorders, consciousness
10. Physiology and pathophysiology of vegetative nervous
system
11. Physiology of the locomotive apparatus.Inflammatory and degenerative diseases.
12. Skin and skin derivatives, functions and malfunctions. Autoimmune
diseases
13. Contaginous and parasitic diseases, anthropozoonoses.
Temoerature.
14. Final consultations
Seminars:
1. Organization of lessons, work safety, ethical aspects of work with laboratory animals, experimental project, approval process
2. Collection of biologic. materialand its examination. Laboratory animals - propedeutics. Anesthesia
3. Imaging techniques in examination, endoscopy. Practical examination methods.
4. Hormonal processes in the reproductive system. Prenatal diagnostic tests.
5. Laboratory examination methods - basics of the good laboratory practice, interpretation of results
6. Laboratory examination methods - microbiological and immunological examination, stress tests, interpreting
7. Molecular diagnostics and paternity testing
8. Cytogetetics, chromosomal aberations
9. Internal environment, acid-base balance. Regulation of blood pressure
10. Electrophysiological examination methods
11. Diseases of the circulatory apparatus and the manifestations demonstrated on an experimental model
12. Visiting Museum of Pathology
13. Visiting laboratories, experimental models
14. Course credit approval
Study resources and literature
    recommended literature
  • GRANT, Allison. Ross & Wilson pathophysiology. [London]: Elsevier, 2024, vii, 408. ISBN 9780702077715. info
  • SILBERNAGL, Stefan and Florian LANG. Color atlas of pathophysiology. 3rd edition. Stuttgart: Thieme, 2016, x, 438. ISBN 9783131165534. info
  • MCCANCE, Kathryn L. and Sue E. HUETHER. Pathophysiology : the biologic basis for disease in adults and children. Edited by Valentina L. Brashers - Neal S. Rote. Seventh edition. St. Louis: Elsevier, 2014, xxvi, 1810. ISBN 9780323088541. info
Approaches, practices, and methods used in teaching
In person form lectures, seminars, exercises, exercises in selected examination techniques, acquired data analysis, consultations.
Method of verifying learning outcomes and course completion requirements
For the admission to the exam is necessary 100% participation in the exercises and fulfillment of the assignment of the exercise. Each teacher decides the fulfillment of the obligations arising from the exercises they teach. A seminar thesis on given topics, written test or an interview can be assigned. Completion of the course - oral exam. Students randomly choose three questions from three areas. It is necessary to answer all three questions.
Language of instruction
English
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