aFAFT1_13 Pharmaceutical Technology I

Faculty of Pharmacy
Spring 2026

The course is not taught in Spring 2026

Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
PharmDr. Jan Elbl, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
PharmDr. Jan Elbl, Ph.D. (seminar tutor)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
Mgr. Sylvie Pavloková, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Prerequisites (in Czech)
aFAFY1_13 Physical Pharmacy && aFAFC2_14 Human Phys. and Pathophys II.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The aim of the course is to acquaint students with the basics and principles of drug formulation, methods and processes used in the design and development of dosage forms and stability studies.
Learning outcomes
After completing the course, the student will be able to:
– identify and classify the dosage form into one of the three generations according to the nature of the drug release;
– describe procedures leading to increased bioavailability of drugs;
– describe the production and evaluation of mucoadhesive systems, ion exchangers and biological dosage forms;
– describe the principles of 3D printing for the preparation of dosage forms;
– describe in vitro – in vivo models in drug development.
Key topics
  • Introduction to the field of pharmaceutical technology. Drug (active substance), dosage forms, medicine. The importance of biopharmacy and pharmacokinetics in the formulation and development of pharmaceuticals. Generation of dosage forms. Dosage forms of the first generation.
  • Dosage forms of the second and the third generation.
  • Physico-chemical factors influencing the effect of the drug.
  • Biological factors influencing the effect of the drug.
  • Preformulation studies, drug formulation, drug validation.
  • Increasing bioavailability of poorly water soluble drugs by their modification.
  • Increasing bioavailability of poorly water soluble drugs by technological methods facilitating drug dissolution.
  • Lipophilic formulations for increasing bioavailability of poorly water-soluble drugs.
  • Liquid-solid systems and their application in pharmacy. Dosage forms based on these systems.
  • Mucoadhesive systems and their application in pharmacy. Dosage forms based on these systems.
  • 3D printing and its application in pharmacy. Dosage forms based on this technology.
  • Ion exchangers and their application in pharmacy. Dosage forms based on ion exchangers. Production of biological dosage forms.
  • In vitro – in vivo models in drug development.
Study resources and literature
    recommended literature
  • 3D & 4D printing methods for pharmaceutical manufacturing and personalised drug delivery : opportunities and challenges. Edited by Dimitrios Lamprou. Cham: Springer, 2023, xiii, 321. ISBN 9783031341182. info
  • Drug delivery : principles and applications. Edited by Binghe Wang - Longqin Hu - Teruna Siahaan. Second edition. Hoboken, New Jersey: Wiley, 2016, 1 online. ISBN 9781118833230. URL info
  • Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Edited by Patrick J. Sinko - Yashveer Singh. Sixth edition. Philadelphia: Wolters Kluwer, 2011, viii, 659. ISBN 9781609134020. info
Approaches, practices, and methods used in teaching
lectures
Method of verifying learning outcomes and course completion requirements
oral exam
Language of instruction
English
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