FAFT1_14 Pharmacology I

Faculty of Pharmacy
Spring 2020
Extent and Intensity
3/3/0. 7 credit(s). Type of Completion: z (credit).
Teacher(s)
MUDr. PharmDr. Marek Frydrych, Ph.D. (lecturer)
PharmDr. Bc. Kateřina Horská, Ph.D. (lecturer)
MUDr. Marta Chalupová, Ph.D. (lecturer)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
doc. RNDr. Eva Račanská, CSc. (lecturer)
MUDr. PharmDr. Marek Frydrych, Ph.D. (seminar tutor)
PharmDr. Bc. Kateřina Horská, Ph.D. (seminar tutor)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
doc. RNDr. Eva Račanská, CSc. (seminar tutor)
Guaranteed by
doc. PharmDr. Peter Kollár, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Pharmacology is a science that studies interactions of medical substances and organisms on various morphological and physiological levels. It focuses on mechanisms and time progress of medicines in organisms (pharmacokinetics), and on medicines impact mechanisms on an organism (pharmacodynamics). Certain toxicology sections (science on toxins) constitute a part of the pharmacology in the area of undesirable effects as well.

Syllabus
General pharmacology
Pharmacokinetics
Types of drug transport (translocation) in organism
Absorption of drugs, influencing factors
Distribution of drugs in organism, influencing factors
Distribution - physiological barriers
Metabolism of drugs, influencing factors
Mechanisms of drugs excretion, influencing factors
Basic pharmacokinetic parameters, calculation, practical significance in pharmacotherapy
Factors influencing pharmacokinetics
Pharmacodynamics
Mechanisms of drugs action
Quantitative (graded) and quantal (population) dose (concentration)- response relationships. Therapeutic index
Drugs interactions
Adverse and toxic effects of drugs
Drug dependence, basic types
Preclinical testing of drugs
Clinical testing of drugs
Pharmacology and human genome (pharmacogenomics, gene therapy)
Special Pharmacology
Pharmacology of the peripheral nervous system
Autonomic nervous system - muscarinic agonists (parasympathomimetics). Inhibitors of cholinesterase
Autonomic nervous system - muscarinic antagonists (parasympatholytics)
Autonomic nervous system - adrenoceptor agonists (sympathomimetics)
Autonomic nervous system - adrenoceptor antagonists (sympatholytics)
Neuromuscular-blocking drugs
Local anaesthetics
Pharmacology of cardiovascular system
Pharmacotherapy of chronic heart failure
Antidysrhythmic drugs
Pharmacotherapy of coronary heart disease: Therapy of angina pectoris. Overview of therapy of acute myocardial infarction
Vasoactive drugs
Inhibitors of angiotensin-converting enzyme. Antagonists of angiotensin receptors AT1
Pharmacotherapy of arterial hypertension
Pharmacology of the kidney
Diuretics
Drugs acting on haemostasis and fibrinolysis
Drugs acting on the haemopoietic system: Treatment of anaemia by iron, folic acid and vitamin B12. Overview of haemopoietic growth factors
Atherosclerosis and lipoprotein metabolism
Atherosclerosis risk factors, pharmacological and non-pharmacological prevention
Pharmacotherapy of dyslipidaemias
Literature
    required literature
  • Whalen K. Lippincott Illustrated Reviews: Pharmacology, 7th edition. Lippincott Williams & Wilkins, USA, 2018. ISBN 978-1496384133. info
  • Humphrey P. Rang, Maureen M. Dale, James M. Ritter and Rod J. Fl. Rang & Dale's Pharmacology, 8th Edition. 2016. ISBN 978-0702053627. info
    recommended literature
  • Trevor A, Katzung B, Masters S., Knuidering-Hall M. Katzung & Trevor's Pharmacology Examination and Board Review. McGraw-Hill Medical, 2012. ISBN 0071789235. info
  • Katzung BG. Basic and Clinical Pharmacology. McGraw-Hill Medical, 2011. ISBN 978-0071764018. info
Language of instruction
English
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Listed among pre-requisites of other courses
Teacher's information
Conditions for successful completion of seminars and obtaining credits are as follows:
1. Complete all seminars (100% Attendance is necessary)
2. To score at least 65% to pass the credit test.
The course is also listed under the following terms Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2020, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2020/FAFT1_14