C6220 Clinical Biochemistry

Faculty of Science
autumn 2021
Extent and Intensity
4/0/0. 4 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Taught in person.
prof. RNDr. Michaela Wimmerová, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Michaela Wimmerová, Ph.D.
Department of Biochemistry - Chemistry Section - Faculty of Science
Contact Person: prof. RNDr. Michaela Wimmerová, Ph.D.
Supplier department: Department of Biochemistry - Chemistry Section - Faculty of Science
Wed 13:00–16:50 B11/205
Prerequisites (in Czech)
C4182 Biochemistry II || C3580 Biochemistry || C5720 Biochemistry
předpokládá se absolvování základní přednášky z biochemie a znalost základních metabolických drah na úrovni buňky.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The goal of this course is to provide general basic knowledge about biochemical and molecular aspects of pathobiological processes and use of biochemical tests to obtain diagnostic information. The course consisted from two part, pathobiochemistry and methods in clinical biochemistry.

At the end of the course students should be able to:
understand the basic physiological events in healthy human organism;
understand and explain relationships between analytical parameters determined in clinical biochemistry laboratories ans their diagnostic indication;
interpret basic non-physiological results and give them into a context of the potential disease
Learning outcomes
Student will be able to - understant basic function of human organism in relation with the commonly used biochemical markers connected with clinical biochemistry diagnostics - describe basic methods used in clinical biochemistry laboratories
  • SECTION ONE: Laboratory techniques
  • Basic laboratory principles and calculations
  • Collection and handling of patient specimens
  • Methods in clinical biochemistry
  • Analysis of metabolites, proteins and enzymes
  • Automation
  • Laboratory statistics, reference values, quality control
  • Evaluation of methods
  • Section TWO: Pathobiochemistry
  • Body water and electrolytes
  • Renal function
  • Acid-base control and acid-base disorders
  • Liver function
  • Diabetes mellitus
  • Disorders of lipid and lipoprotein metabolism
  • Gastrointestinal function, pancreatic function, digestive disease
  • Bone disease
  • Biochemistry of muscle
  • Inborn errors of metabolism
  • Endocrine function
  • Tumor markers
  • ZIMA, Tomáš. Laboratorní diagnostika. 1. vyd. Praha: Galén, 2002. xxxii, 728. ISBN 8072622013. info
  • RACEK, Jaroslav. Klinická biochemie (Clinical chemistry). 1st ed. Praha: Galén, 1999. 316 pp. ISBN 80-7262-023-1. info
  • Clinical biochemistry :metabolic and clinical aspects. Edited by S. K. Bangert - William J. Marshall. New York: Churchill Livingstone, 1995. xi, 854 s. ISBN 0-443-04341-8. info
  • MASOPUST, Jaroslav. Klinická biochemie. Požadování a hodnocení biochemických vyšetření. (Clinical chemistry.). 1st ed. Praha: Karolinum, 1998. 832 pp. část I. a část II. ISBN 80-7184-649-3. info
  • Clinical guide to laboratory tests. Edited by Norbert W. Tietz. 3rd ed. Philadelphia: W.B. Saunders Company, 1995. xxxix, 109. ISBN 0-7216-5035-X. info
  • KARLSON, Peter, Wolfgang GEROK and W. GROSS. Pathobiochemie. 1. vyd. Praha: Academia, 1987. 480 s. info
  • RACEK, Jaroslav. Klinická biochemie. 2., přeprac. vyd. Praha: Galén, 2006. 329 s. ISBN 8072623249. info
Teaching methods
Assessment methods
written exam
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught last offered.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2021/C6220