C6222 Clinical Biochemistry II

Faculty of Science
Spring 2024
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Taught in person.
prof. RNDr. Michaela Wimmerová, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Michaela Wimmerová, Ph.D.
Department of Biochemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Michaela Wimmerová, Ph.D.
Supplier department: Department of Biochemistry – Chemistry Section – Faculty of Science
Mon 19. 2. to Sun 26. 5. Thu 16:00–17:50 B11/335
Prerequisites (in Czech)
( PROGRAM ( B - LGM ) && C6219 Clinical Biochemistry ) || ( PROGRAM ( N - BIC ) && ( C6220 Clinical Biochemistry || C6221 Clinical Biochemistry ))
Předpokládá se absolvování základní přednášky z biochemie, znalost základních metabolických drah na úrovni buňky a absolvování předmětu Klinická biochemie I. (C6219 nebo C6221). Studenti programu Biochemie si zapisují v magisterském studiu.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The goal of this course is to provide general basic knowledge about biochemical and molecular aspects of pathobiological processes and use of biochemical tests to obtain diagnostic information. The course is focused mainly on analytical aspects and methods in in clinical biochemistry.

At the end of the course students should be able to:
understand the basic physiological events in healthy human organism;
understand and explain relationships between analytical parameters determined in clinical biochemistry laboratories ans their diagnostic indication;
interpret basic non-physiological results and give them into a context of the potential disease
Learning outcomes
Student will be able to - understant basic function of human organism in relation with the commonly used biochemical markers connected with clinical biochemistry diagnostics - describe basic methods used in clinical biochemistry laboratories
  • Laboratory techniques
  • Basic laboratory principles and calculations
  • Collection and handling of patient specimens
  • Methods in clinical biochemistry
  • Analysis of metabolites, proteins and enzymes
  • Automation
  • Laboratory statistics, reference values, quality control
  • Evaluation of methods
  • DASTYCH, Milan. Klinická biochemie : bakalářský obor Zdravotní laborant. 1. dotisk 3. vyd. Brno: Masarykova univerzita. ISBN 978-80-210-7788-1. 2021. info
  • RACEK, Jaroslav. Klinická biochemie. 2., přeprac. vyd. Praha: Galén. 329 s. ISBN 8072623249. 2006. info
  • ZIMA, Tomáš. Laboratorní diagnostika. 1. vyd. Praha: Galén. xxxii, 728. ISBN 8072622013. 2002. info
  • RACEK, Jaroslav. Klinická biochemie (Clinical chemistry). 1st ed. Praha: Galén. 316 pp. ISBN 80-7262-023-1. 1999. info
  • MASOPUST, Jaroslav. Klinická biochemie. Požadování a hodnocení biochemických vyšetření. (Clinical chemistry.). 1st ed. Praha: Karolinum. 832 pp. část I. a část II. ISBN 80-7184-649-3. 1998. info
  • Clinical biochemistry :metabolic and clinical aspects. Edited by S. K. Bangert - William J. Marshall. New York: Churchill Livingstone. xi, 854 s. ISBN 0-443-04341-8. 1995. info
  • Clinical guide to laboratory tests. Edited by Norbert W. Tietz. 3rd ed. Philadelphia: W.B. Saunders Company. xxxix, 109. ISBN 0-7216-5035-X. 1995. info
  • KARLSON, Peter, Wolfgang GEROK and W. GROSS. Pathobiochemie. 1. vyd. Praha: Academia. 480 s. 1987. info
Teaching methods
Assessment methods
Written exam. The written test emphasizes understanding connections and rules when performing analyses in Clinical Biochemistry. Huge emphasis is placed on understanding the laws of enzyme kinetics and the rules both necessary for determining the activities of enzymes and for their use as analytical reagents. Attention should be paid to the real possibility of detecting the investigated analytes. All the necessary parts are discussed in detail during the lectures, where the lecture expands the study material uploaded in IS, and this joint information is sufficient to pass the exam. In the case of self-study, an independent study of the necessary literature is required.
Language of instruction
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2023, Spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/spring2024/C6222