aVLBC0321p Biochemistry I - lecture

Lékařská fakulta
podzim 2024
Rozsah
3/0/0. 45. 3 kr. Ukončení: z.
Vyučováno kontaktně
Vyučující
doc. RNDr. Jiří Dostál, CSc. (přednášející)
RNDr. Hana Paulová, CSc. (přednášející)
Mgr. Jiří Slanina, Ph.D. (přednášející)
prof. RNDr. Eva Táborská, CSc. (přednášející)
doc. RNDr. Josef Tomandl, Ph.D. (přednášející)
Iva Audy (pomocník)
MUDr. Michaela Králíková, Ph.D. (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Po 10:00–12:50 B11/334
Předpoklady
aVLBI0222p Lékařská biologie II - př && aVLBF011p Biophysics - lecture
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to introduce students to the basic metabolic pathways and processes occurring at the cellular level in the human organism.
Výstupy z učení
Upon completion of the course, student will be able to:
- understand the meaning of basic chemical concepts and apply them in describing biochemical processes in an organism.
- discuss the properties and functions of enzymes.
- describe the basic catabolic and anabolic pathways of cellular metabolism of carbohydrates, lipids, and proteins.
- characterize the principles of energy acquisition, utilization, and storage in the cell.
- explain protein synthesis, beginning with the processes of replication and transcription, including posttranslational modifications.
- understand the relationship between the structure and function of proteins, e.g. haemoglobin, collagen, elastin.
- characterize the causes of some diseases at the molecular level.
Osnova
  • Electrolytes, ion activity. Weak acids/bases. Buffers. Bioenergetics, Gibbs energy, high-energy compounds. Redox reaction.
  • Enzymes. Characteristic features of biocatalysis. Cofactors.
  • Metabolism of nutrients. Citrate cycle. Respiratory chain. Oxidative phosphorylation.
  • Carbohydrates in nutrition. Carbohydrate digestion. Basic features of glucose metabolism. Glucose transport into cells. Glycolysis. Gluconeogenesis.
  • Glycogen. Metabolism of fructose, galactose, lactose. The pentose phosphate pathway. Glycosaminoglycans, proteoglycans.
  • Lipids and fatty acids. Surfactants. Lipophilic vitamins. Lipids in nutrition. Lipid digestion. Fatty acid metabolism. PUFA synthesis. Metabolism of ketone bodies.
  • Metabolism of triacylglycerols, glycerophospholipids, sphingolipids. Lipoperoxidation. Biosynthesis and importance of eicosanoids.
  • Metabolism of cholesterol, bile acids. Biosynthesis of calciols.
  • Amino acids. Peptides. Structure of proteins, myosin, collagen, immunoglobulins. Hemoglobin, myoglobin. Hemoglobinopathies.
  • Digestion and intracellular degradation of proteins. General features in catabolism of amino acids. Ammonia metabolism and toxicity.
  • Catabolism of amino acids, congenital disorders of amino acid metabolism. Synthesis of non-essential amino acids.
  • Conversions of amino acids into low molecular weight products. Heme synthesis, porphyria.
  • Metabolism of purine/pyrimidine nucleotides.
  • Structure of DNA, RNA. Replication and corrections. Transcription and its regulation, post-transcriptional modifications.
  • Protein synthesis. Folding, transport and sorting of proteins in the cell. Post-translational modification.
  • Biosynthesis of collagen, elastin.
Literatura
    povinná literatura
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
  • Essentials of Medical Chemistry and Biochemistry (Ed. Dostál J.). Download: https://portal.med.muni.cz/article-623-essentials-of-medical-chemistry-and-biochemistry.html
    doporučená literatura
  • LIEBERMAN, Michael a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • VASUDEVAN, D. M., S. SREEKUMARI a Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016, xvi, 718. ISBN 9789385999741. info
  • KOOLMAN, Jan a Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
Výukové metody
Lectures.
Metody hodnocení
Credit, no knowledge testing.
The course is followed in the 4th semester by Biochemistry II. The content of Biochemistry I is included in the Biochemistry II exam.
Vyučovací jazyk
Angličtina
Další komentáře
Předmět je vyučován každoročně.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích podzim 2016, podzim 2017, podzim 2018, podzim 2019, podzim 2020, podzim 2021, podzim 2022, podzim 2023.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/med/podzim2024/aVLBC0321p