VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
doc. Mgr. Zdenka Fohlerová, Ph.D. (assistant)
Mgr. David Galuška (assistant)
MUDr. Lenka Gescheidtová, Ph.D. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
Mgr. Patrícia Kittová (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
MUDr. Mgr. Pavel Šmak (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Mgr. Jan Víteček, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:20–9:00 B22/116 aula
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
After completing the course, the student is able to:
- explain the interrelationships between the metabolism of nutrients in different states of the organism.
- describe the metabolic characteristics of the main organs and tissues and the main disorders, and discuss their connection with diseases.
- explain the principles of metabolism regulation at all levels.
- understand the principles of maintaining homeostasis in the organism and acid-base balance, including solving model situations.
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
Syllabus
  • Blood plasma lipids. Metabolism of lipoproteins.
  • Overview of nutrient metabolism in different states.
  • Metabolic functions of liver. Catabolism of heme. Biochemical tests for liver diseases.
  • Metabolism of iron and copper. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and Na+, K+ ions balance, osmolality and volume of ECF.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases. Parameters of acid-base status.
  • Biochemical functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • General mechanisms of action of signal molecules. Hormone receptors.
  • Steroid and thyroid hormones.
  • Nervous tissue. Cerebrospinal fluid. Neurosecretion. Neurotransmitters and their receptors.
  • Endothelial cells. Blood-coagulation cascade, inhibition of clotting. Fibrinolysis.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Bone tissue. Articular cartilage and skin.
  • Biochemistry of blood cells. Major proteins of blood plasma.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015, 669 stran. ISBN 9788097015688. info
  • Doporučovaná literatura z lékařské fyziologie v předmětu VLFY0422p.
Teaching methods
Lectures
Assessment methods
Oral exam. Student draws two questions from Biochemistry I and two questions from Biochemistry II. The student answers the questions without preparation.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů VLBC0422s, VLBC0422c a VLBC0422t.
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2024/VLBC0422p/
The basic concepts and topics covered in the exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2023
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Marcela Nečasová (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:30–9:20 B22/116 aula
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
After completing the course, the student is able to:
- explain the interrelationships between the metabolism of nutrients in different states of the organism.
- describe the metabolic characteristics of the main organs and tissues and the main disorders, and discuss their connection with diseases.
- explain the principles of metabolism regulation at all levels.
- understand the principles of maintaining homeostasis in the organism and acid-base balance, including solving model situations.
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
Syllabus
  • Blood plasma lipids. Metabolism of lipoproteins.
  • Overview of nutrient metabolism in different states.
  • Metabolic functions of liver. Catabolism of heme. Biochemical tests for liver diseases.
  • Metabolism of iron and copper. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and Na+, K+ ions balance, osmolality and volume of ECF.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases. Parameters of acid-base status.
  • Biochemical functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • General mechanisms of action of signal molecules. Hormone receptors.
  • Steroid and thyroid hormones.
  • Nervous tissue. Cerebrospinal fluid. Neurosecretion. Neurotransmitters and their receptors.
  • Endothelial cells. Blood-coagulation cascade, inhibition of clotting. Fibrinolysis.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Bone tissue. Articular cartilage and skin.
  • Biochemistry of blood cells. Major proteins of blood plasma.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015, 669 stran. ISBN 9788097015688. info
  • Doporučovaná literatura z lékařské fyziologie v předmětu VLFY0422p.
Teaching methods
Lectures
Assessment methods
Oral exam. Student draws two questions from Biochemistry I and two questions from Biochemistry II. The student answers the questions without preparation.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů VLBC0422s, VLBC0422c a VLBC0422t.
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2024/VLBC0422p/
The basic concepts and topics covered in the exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught partially online.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: prof. RNDr. Eva Táborská, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:30–9:20 B22/116 aula
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Plasma lipids. Lipoprotein metabolism.
  • Nutrient metabolism in different conditions.
  • Biochemical functions of the liver. Heme catabolism.
  • Iron and copper metabolism. Biotransformation of xenobiotics. Ethanol metabolism.
  • Homeostasis of water, Na+ and K + ions. Regulation of osmolality and volemia.
  • Acid-base balance. Transport of O2 and CO2 in blood. Buffer bases.
  • Biochemical functions of the kidneys. Filtration functions. Tubular resorption and secretion.
  • Steroid and thyroid hormones.
  • Membrane and intracellular receptors. Nervous tissue metabolism. Neurotransmitters, synapses.
  • Metabolism of calcium, magnesium, phosphates, fluorine and iodine.
  • Vascular endothelium. Hemocoagulation, fibrinolysis.
  • Biochemistry of blood elements. The most important blood plasma proteins.
  • Extracellular matrix. Connective tissue metabolism.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Supplementary materials: https://is.muni.cz/auth/el/med/jaro2022/VLBC0422s/um/
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • BORON, Walter F. and Emile L. BOULPAEP. Medical physiology. Third edition. Philadelphia: Elsevier, 2017, xii, 1297. ISBN 9781455743773. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015, 669 stran. ISBN 9788097015688. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
Teaching methods
Lectures
Assessment methods
Oral exam - students will draw two questions from Biochemistry I and two questions from Biochemistry II.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2022/VLBC0422p/
The basic concepts and topics covered in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2023, spring 2024.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Taught online.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 8:00–9:50 B22/116 aula
Prerequisites (in Czech)
( VLBI0222p Biology II-lect. || VSBI0222p Biology II-lect. ) && VLBF011p Biophysics-lect. && VLBC0321s Biochemistry I sem && VLBC0321c Biochemistry I && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes).
  • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Steroid and thyroid hormones – biosynthesis, secretion, and effects.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.
  • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
  • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. 1st ed. Praha: Grada, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Podklady k přednáškám dostupné v IS.
    recommended literature
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • VASUDEVAN, DM, S SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Prvé slovenské vydanie. Bratislava: Balneotherma, 2015, 670 pp. ISBN 978-80-970156-8-8. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSBC041s).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination is only oral.Exam questions and other detailed information are available in the Study Materials of the course.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2022, spring 2023, spring 2024.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2020
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Monika Šudáková
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 8:00–9:50 B22/116 aula, except Tue 7. 4., except Tue 26. 5.
Prerequisites (in Czech)
( VLBI0222p Biology II-lect. || VSBI0222p Biology II-lect. ) && VLBF011p Biophysics-lect. && VLBC0321s Biochemistry I sem && VLBC0321c Biochemistry I && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes).
  • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Steroid and thyroid hormones – biosynthesis, secretion, and effects.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.
  • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
  • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. 1st ed. Praha: Grada, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Podklady k přednáškám dostupné v IS.
    recommended literature
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • VASUDEVAN, DM, S SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Prvé slovenské vydanie. Bratislava: Balneotherma, 2015, 670 pp. ISBN 978-80-970156-8-8. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSBC041s).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination has writen and oral part. The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (personal university ID /UCO/ and pass-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are from practical exercises. Remaining 15 questions cover essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas. - to draw metabolic pathways in structural formulas with a short comment. - where appropriate, to draw a picture. A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2021, spring 2022, spring 2023, spring 2024.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2019
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:00–8:40 B22/116 aula
Prerequisites (in Czech)
( VLBI0222p Biology II-lect. || VSBI0222p Biology II-lect. ) && VLBF011p Biophysics-lect. && VLBC0321s Biochemistry I sem && VLBC0321c Biochemistry I && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes).
  • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Steroid and thyroid hormones – biosynthesis, secretion, and effects.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.
  • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
  • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSBC041s).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination has writen and oral part. The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (personal university ID /UCO/ and pass-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are from practical exercises. Remaining 15 questions cover essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas. - to draw metabolic pathways in structural formulas with a short comment. - where appropriate, to draw a picture. A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
Spring 2018
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 8:00–9:50 B22/116 aula
Prerequisites (in Czech)
( VLBI0222p Biology II-lect. || VSBI0222p Biology II-lect. ) && VLBF011p Biophysics-lect. && VLBC0321s Biochemistry I sem && VLBC0321c Biochemistry I && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes).
  • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Steroid and thyroid hormones – biosynthesis, secretion, and effects.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.
  • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
  • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSBC041s).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination has writen and oral part. The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (personal university ID /UCO/ and pass-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are from practical exercises. Remaining 15 questions cover essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas. - to draw metabolic pathways in structural formulas with a short comment. - where appropriate, to draw a picture. A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Czech
Further Comments
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2017, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.

VLBC0422p Biochemistry II - lecture

Faculty of Medicine
Spring 2017
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 8:00–9:50 B22/116 aula
Prerequisites (in Czech)
( VLBI0222p Biology II-lect. || VSBI0222p Biology II-lect. ) && VLBF011p Biophysics-lect. && VLBC0321s Biochemistry I sem && VLBC0321c Biochemistry I && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL
  • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes).
  • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders.
  • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status.
  • Normal renal functions. Glomerular filtration. Tubular resorption and secretion.
  • Steroid and thyroid hormones – biosynthesis, secretion, and effects.
  • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.
  • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism.
  • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
  • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis.
  • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSBC041c and VSBC041s).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam.
The examination has writen and oral part. The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (personal university ID /UCO/ and pass-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are from practical exercises. Remaining 15 questions cover essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas. - to draw metabolic pathways in structural formulas with a short comment. - where appropriate, to draw a picture. A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Czech
Further Comments
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (recent)