aVLIM051p Imunologie - přednáška

Lékařská fakulta
podzim 2018
Rozsah
1/0/0. 15. 3 kr. Ukončení: zk.
Vyučující
prof. MUDr. Jiří Litzman, CSc. (přednášející)
prof. MUDr. Jindřich Lokaj, CSc. (přednášející)
Garance
prof. MUDr. Jiří Litzman, CSc.
Ústav klinické imunologie a alergologie - Společná pracoviště s Fakultní nemocnicí u sv. Anny v Brně - Lékařská fakulta
Kontaktní osoba: prof. MUDr. Jiří Litzman, CSc.
Dodavatelské pracoviště: Ústav klinické imunologie a alergologie - Společná pracoviště s Fakultní nemocnicí u sv. Anny v Brně - Lékařská fakulta
Rozvrh
St 19. 9. 16:30–19:10 014, St 26. 9. 16:30–19:10 N02303, St 3. 10. 16:30–19:10 N02303, St 10. 10. 16:30–19:10 N02303, St 17. 10. 16:30–19:10 N02303, St 24. 10. 16:30–19:10 N02303, St 31. 10. 16:30–19:10 N02303, St 7. 11. 16:30–19:10 N02303, St 14. 11. 16:30–19:10 N02303, St 21. 11. 16:30–19:10 N02303, St 28. 11. 16:30–19:10 N02303, St 5. 12. 16:30–19:10 N02303
Předpoklady
( aVLBC0422p Biochemie II - předn. || VSBC041p Biochemie II - předn. ) && ( VSFY0422p Fyziologie II - přednáška || aVLFY0422p Fyziologie II - přednáška )
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory
Cíle předmětu
The course covers basic aspects of the structure and function of the immune system in humans. Topics include mechanisms of non- specific immunity with main emphasis on the inflammatory process, such as humoral and cellular branches of the specific immune response. It includes mainly mechanisms of activation of the immune response and its regulation. Special emphasis is given to immune response to microbes and immunoprophylaxis to infectious and non-infectious diseases. After finishing the course the students will understand and be able to explain the mechanisms of the immune response in physiology, such as immune system disturbances leading to immunopathological diseases.
Výstupy z učení
- The student will understand basic mechanisms of functioning of the immune system, functional characteristics of specific and non-specific immune response, and the interrelationship of these reactions;
- The student will understand the importance of the immune system in defense against microbes and tumor growth as well as the principles of active and passive artificial immunization;
- The student will become acquainted with the regional specificity of the individual compartments of the immune system;
- The student will be acquaint with the mechanisms of immune tolerance and the mechanisms of its breakdown leading to autoimmune diseases;
- The student will be familiar with the principles of immunological hypersensitivity and the consequences leading to the development of hypersensitivity reactions;
- The student will be acquainted with basic principles of pharmacological influence of immune reactivity;
- The sudent will be acquainted with the most important primary and secondary immunodeficient states;
Osnova
  • Immunology in medicine. Medical subject allergology and clinical immunology. Physiology and pathology of the immune system.
  • Immunological concept of “own”, “foreign”, “dangerous”.
  • Anatomy and cellular elements of the immune system.
  • Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation.
  • B lymphocytes and immunoglobulins.Genetic basis of immunoglobulin heterogeneity.Biological properties of antibodies.
  • T-lymphocytes, their development and effector functions. Polarisation of T-lymphocytes (T1, T2, Th17). Cytotoxicity. Cytokines. Major histocompatibility complex: structure, function.
  • Activation of T and B cells by antigen.Interactions between antigen-presenting cells and T- and B-lymphocytes.
  • Regulation of the immune reaction.
  • Compartmentalization of the immune response. Mucosal immunity.
  • Immunity against infectious agents. Microbial antigens.
  • Active and passive immunisation.
  • Age factor and immune system in humans
Literatura
    doporučená literatura
  • ABBAS, Abul K., Andrew H. LICHTMAN a Shiv PILLAI. Basic immunology : functions and disorders of the immune system. Fifth edition. St. Louis: Elsevier, 2016. x, 335. ISBN 9780323390828. info
Výukové metody
The subject is given in a form of lectures
Metody hodnocení
Oral exam
Vyučovací jazyk
Angličtina
Informace učitele
Kontaktní osoba: Prof. MUDr. J. Litzman, CSc., tel: +420 54318 3125 Oral exam is composed of two questions. One of them is from the subject of a theoretical immunology, the second one from the patophysiogy of the immune system. A credit from the subject aVLIM051c is required for the exam.
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Předmět je zařazen také v obdobích podzim 2017, podzim 2019.