LF:VLPF0521p Pathol. physiology I - lecture - Course Information

VLPF0521p Pathological Physiology I - lecture

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: z (credit).

Teacher(s)

prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
Věra Ježková (assistant)

Guaranteed by

prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine

Timetable

Wed 18. 9. to Wed 2. 10. Wed 14:00–15:40 B22/116 aula, Wed 16. 10. to Wed 18. 12. Wed 14:00–15:40 B22/116 aula; and Wed 9. 10. 14:00–15:40 B11/114

Prerequisites (in Czech)

( VLFY0422p Physiology II - lecture || VSFY0422p Physiology II - lecture ) && ( VSBC041p Biochemistry II -l || VLBC0422p Biochemistry I -lect. ) && ( VLAN0222p Anatomy II l || VSAN0333p Anatomy III - lec. ) && ( VLHE0322p Histology and embryology II -l || VSHE0322p Histology and embryology II -l ) && VLLM0421c Med.Microbiol.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• General Medicine (programme LF, M-VL)

Course objectives

The aim of the subject is to teach students to be able to answer a sufficient number of pathophysiologically asked questions "why".

Learning outcomes

Student characterizes state of healthy and disease
Student calls main sources of interindividual variability
Student discusses influences which determined population frequencies of alleles
Student distinguishes mutation types according to the mechanism
Student describes base principles of methods detecting human genome and its variability
Student summarises base types of DNA reparation
Student describes base characteristics of monogenic diseases
Student discusses base principles and indications of gene therapy
Student knows an importance of the term of pharmacogenetics
Student demonstrates understanding of an influence of external factors on disease development
Student characterizes base features of complex diseases
Student summarises importance of epigenetics
Student describes pathophysiology of stress reaction
Student defines homeostasis term
Student is able to describe base principles of multicellular organism functioning
Student identifies disorder of growth and development from ontogenetic point of view
Student describes results of hypoxia including HIF 1 program
Student explains a difference between local and systemic inflammation
Student explains pathogenesis of oedema
Student discusses etiopathogenesis of the most important ion homeostasis disturbances
Student distinguishes base acid base balance disturbances and possibilities of their compensation
Student applies knowledge of volume and tonicity regulation
Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy
Student knows principles and performance of base coagulation tests
Student explains wound healing process with examples of pathological healing
Student knows pathophysiology of urgent states in oncology diseases
Student explains an importance of micronutrients abnormalities
Student knows results of abnormal vitamin levels
Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins
Student discusses pathophysiology of protein metabolism
Student understands the base principles of regulation of glucose
Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders
Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes
Student describes onset, signs and results of heart and vessels remodelling
Student applies chronobiology knowledge for explication of different pathophysiological changes

Syllabus

• W1: Pathophysiology as a medical discipline – health vs. disease – definition of major concepts (aetiology, pathogenesis, syndrome/symptom etc.) [Prof. MUDr. Kateřina Kaňková, PhD.]
• W2: Pathophysiology of circulatory system I – myocardial metabolism - atherosclerosis – coronary heart disease [Prof. MUDr. Kateřina Kaňková, PhD.]
• W3: Pathophysiology of circulatory system II – pressure and volume overload (esp. systemic arterial hypertension) and heart and periph. blood vessel remodelling [Prof. MUDr. Kateřina Kaňková, PhD.]
• W4: Pathophysiology of circulatory system III – pressure and volume overload (esp. heart and valve defects, cardiomyopathies) - systolic and diastolic dysfunction – heart failure [Prof. MUDr. Anna Vašků, CSc.]
• W5: Pathophysiology of respiratory system I – blood gases exchange – ventilation / diffusion / perfusion) disorders – ventilation-perfusion mismatch [Prof. MUDr. Kateřina Kaňková, PhD.]
• W6: Pathophysiology of respiratory system II – control of ventilation – respiratory insufficiency syndromes, pulmonary oedema, respiratory distress syndrome, selected restrictive lung diseases [Prof. MUDr. Kateřina Kaňková, PhD.]
• W7: Pathophysiology of respiratory system III – obstructive diseases (bronchial asthma and COPD), pulmonary hypertension [Prof. MUDr. Anna Vašků, CSc.]
• W8: Pathophysiology of kidneys I – glomerular haemodynamic – GFR and its quantification – pathology of glom. filtration membrane – proteinuria, glomerulopathies incl. glomerulonephritis) [Prof. MUDr. Kateřina Kaňková, PhD.]
• W9: Pathophysiology of kidneys II – acute (AKI) and chronic renal failure [Prof. MUDr. Kateřina Kaňková, PhD.]
• W10: Cell/tissue/organ/multicellular organism – regulation of proliferation, differentiation and cell death (necrosis vs. apoptosis in the pathophysiological context), tissue injury – cytokines and chemokines, acute inflammation, acute phase reaction - regeneration/reparation – wound healing and its disorders [Doc. RNDr. Monika Pávková-Goldbergová, PhD.]
• W11: Chronic inflammation as a pathologic process – etiopathogenesis, consequences (esp. fibrosis) examples, systemic inflammation (incl. sepsis), multi-organ dysfunction, SIRS, shock [Prof. MUDr. Anna Vašků, CSc.]
• W12: Stress reaction and stress as a pathophysiological phenomenon [Doc. MUDr. Julie Dobrovolná, PhD.]
• W13: Cancer as a systemic disease - paraneoplastic syndromes – cancer cachexia – oncologic emergencies [Prof. MUDr. Anna Vašků, CSc.]
• W14: Topic to be selected by students [Prof. MUDr. Kateřina Kaňková, PhD.]

Literature

required literature
• NEČAS, Emanuel a spol. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000, 377 pp. ISBN 80-246-0051-X. info
• NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, 379 s. ISBN 9788024606750. info
• NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, s. 381-760. ISBN 9788024606743. info
• Ivan Damjanov: Pathophysiology, ISBN 13: 978-1-4160-0229-1, Saunders Elsevier, 2009.

recommended literature
• PÁVKOVÁ GOLDBERGOVÁ, Monika. Patofyziologie v obrazech. Vydání první. Brno: Masarykova univerzita, 2016, 186 stran. ISBN 9788021083233. info

Teaching methods

lecture

Assessment methods

The attendance of lectures and only one absence on practicals per semester are necessary for succesfull accomplishment of the subject. Continous control of knowlledge in practicals is fully in powers of teachers (assays, tests...). Elaborated proceedings of practicals will be put to teachers for credit.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.

Teacher's information

http://www.med.muni.cz/patfyz

• Enrolment Statistics (autumn 2019, recent)
  
• Permalink: https://is.muni.cz/course/med/autumn2019/VLPF0521p