FDSBa_FAF Structural Biology and Chemistry of Drugs

Farmaceutická fakulta
podzim 2025
Rozsah
2/0. 5 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. PharmDr. Oldřich Farsa, Ph.D. (přednášející)
Garance
doc. PharmDr. Oldřich Farsa, Ph.D.
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Biomacromolecules exhibiting primary, secondary, tertiary and even quarternary structures belong among the most important parts of living organisms. Their importance for the therapy of various diseases is also crucial. Proteins, in particular receptor molecules and enzymes are therapetic targets. Some enzymes and modified receptor molecules can be, however, found among medicines as well as protein and peptide hormones, cytokines, haematopoietic factors. Last, but not least members of this series are antibodies. These are mainly therapeutic monoclonal antibodies known as mabs. Also nucleic acids, various DNA and RNA types, can be therapeutic targets, although much more frequently is the role of therapeutic targets for small molecule medicines played by enzymes taking part in their synthesis or post-synthetic modifications. Shorter or longer molecules of less or more modified nucleic acids, namely antisense oligonucleotides and DNA vaccines, can also act as therapeutics. Polysaccharides, the third important group of biogenic macromolecules,, represent also therapeutic targets, however, drugs of this type are of much greater importance (e.g. heparines, chondroitine). The advanced discipline intended for Ph.D. students is just focused on biologic macromolecules both native and modified and their interactions with low molecular drugs and other biopolymers.
Výstupy z učení
Knowledge of selected typed of biomacromolecules, which can serve both as therapeutic targets and drugs, in an extent previously ageed among the examinator, the student and her/his tutor.
Osnova
1. Proteins as drugs and as drug targets. Enzymes. Hydrolases: peptidases, other amidases including histone deacetylases, esterhydrolases, glucosidases. Protein kineses.
2. Nucleic acids and their fragments as drugs and as drug targets. Antisense oligonucleotides, DNA vaccines. Various RNA types (mRNA, tRNA, miRNA) as therapeutic targets.
3. Polysaccharides and oligosaccharides as drugs. Peptidoglycan of the microbial cell wall as a target for antibiotics.
4. Lipides of special functions as therapeutic targets. Mycolic acids of mycobacteria. Lipoteichoic acids of Gram-positive bacteria.
Literatura
    doporučená literatura
  • BRENDA - The Comprehensive Enzyme Information System. URL info
  • MEROPS the Peptidase Database. URL info
  • UniProt Protein Data Base. URL info
  • Rawlings N.D., Savelsen G.S. (eds.). Handbook of proteolytic enzymes. London, San Diego, Waltham, 2013. ISBN 978-0-12-382219-2. info
  • Smith H. C. RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems. Hoboken, New Jersey, USA, 2008. ISBN 9780470262269. info
Výukové metody
Individual study of scientific texts, personal consultations possible.
Metody hodnocení
Oral or written exam. Colloquium is also possible in a case of participation of more students.
Vyučovací jazyk
Angličtina
Předmět je zařazen také v obdobích jaro 2025, jaro 2026.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2025/FDSBa_FAF