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@article{1216381,
author = {Šplíchal, Zbyněk and Bienertová Vašků, Julie and Novák, Jan and Zlámal, Filip and Tomandl, Josef and Tomandlová, Marie and Forejt, Martin and Havlenová, Soňa and Jackowská, Aneta and Vašků, Anna},
article_location = {West Yorkshire},
article_number = {1},
doi = {http://dx.doi.org/10.1179/1476830513Y.0000000100},
keywords = {Adipose tissue; Energy intake; Fat intake; Omentin; Val109Asp polymorphism},
language = {eng},
issn = {1028-415X},
journal = {Nutritional Neuroscience},
title = {The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population},
url = {http://www.maneyonline.com/doi/abs/10.1179/1476830513Y.0000000100},
volume = {18},
year = {2015}
}
TY - JOUR
ID - 1216381
AU - Šplíchal, Zbyněk - Bienertová Vašků, Julie - Novák, Jan - Zlámal, Filip - Tomandl, Josef - Tomandlová, Marie - Forejt, Martin - Havlenová, Soňa - Jackowská, Aneta - Vašků, Anna
PY - 2015
TI - The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population
JF - Nutritional Neuroscience
VL - 18
IS - 1
SP - 41-48
EP - 41-48
PB - Maney Publishing
SN - 1028415X
KW - Adipose tissue
KW - Energy intake
KW - Fat intake
KW - Omentin
KW - Val109Asp polymorphism
UR - http://www.maneyonline.com/doi/abs/10.1179/1476830513Y.0000000100
N2 - Background: Omentin is an adipokine expressed predominantly in visceral adipose tissue, with adipose tissue stromal cells being the main source. Very little is known about the relationship between the genetic variability of the omentin gene and pathophysiology of obesity, although omentin is believed to play an important role in visceral obesity development. The aim of the study was to investigate two common polymorphisms in the omentin gene (rs2274908 and rs2274907) and dietary composition and anthropometric parameters of obesity in the Central European population. Material and methods: A total of 495 subjects were included into the study, they were further dividend into the non-obese, obese, and morbidly obese cohorts. Dietary habits were established using the 7-day food records and selected anthropometric parameters were measured. Results: There were significant differences in genotype distributions of rs2274907 between the obese and morbidly obese cohorts (P = 0.01). In the multivariate modelling, the rs2274907 polymorphism expressed independent prediction role for the daily energy intake, independently on the age and gender (P = 0.03); the TT genotype associated with the lowest (7877 ± 2780 J/day) and the AA genotype with the highest (8764 ± 2467 J/day) average energy intake. The rs2274907 also significantly associated with the daily consumption of fat and proteins. Conclusion: This is, so far, the first study to investigate the polymorphisms in the omentin gene in a large population cohort of obese and non-obese individuals. Based on our results, the rs2274907 polymorphism is associated with the daily energy intake as well as daily intake of fat and protein.
ER -
ŠPLÍCHAL, Zbyněk, Julie BIENERTOVÁ VAŠKŮ, Jan NOVÁK, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Martin FOREJT, Soňa HAVLENOVÁ, Aneta JACKOWSKÁ a Anna VAŠKŮ. The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population. \textit{Nutritional Neuroscience}. West Yorkshire: Maney Publishing, 2015, roč.~18, č.~1, s.~41-48. ISSN~1028-415X. Dostupné z: https://dx.doi.org/10.1179/1476830513Y.0000000100.
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