ŠPLÍCHAL, Zbyněk, Julie BIENERTOVÁ VAŠKŮ, Jan NOVÁK, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Martin FOREJT, Soňa HAVLENOVÁ, Aneta JACKOWSKÁ a Anna VAŠKŮ. The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population. Nutritional Neuroscience. West Yorkshire: Maney Publishing, 2015, roč. 18, č. 1, s. 41-48. ISSN 1028-415X. doi:10.1179/1476830513Y.0000000100.
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Základní údaje
Originální název The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population
Autoři ŠPLÍCHAL, Zbyněk (203 Česká republika, garant, domácí), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí), Jan NOVÁK (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Marie TOMANDLOVÁ (203 Česká republika, domácí), Martin FOREJT (203 Česká republika, domácí), Soňa HAVLENOVÁ (203 Česká republika, domácí), Aneta JACKOWSKÁ (203 Česká republika, domácí) a Anna VAŠKŮ (203 Česká republika, domácí).
Vydání Nutritional Neuroscience, West Yorkshire, Maney Publishing, 2015, 1028-415X.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30105 Physiology
Stát vydavatele Velká Británie
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 2.616
Kód RIV RIV/00216224:14110/15:00082224
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1179/1476830513Y.0000000100
UT WoS 000346538800006
Klíčová slova anglicky Adipose tissue; Energy intake; Fat intake; Omentin; Val109Asp polymorphism
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 9. 7. 2015 10:21.
Anotace
Background: Omentin is an adipokine expressed predominantly in visceral adipose tissue, with adipose tissue stromal cells being the main source. Very little is known about the relationship between the genetic variability of the omentin gene and pathophysiology of obesity, although omentin is believed to play an important role in visceral obesity development. The aim of the study was to investigate two common polymorphisms in the omentin gene (rs2274908 and rs2274907) and dietary composition and anthropometric parameters of obesity in the Central European population. Material and methods: A total of 495 subjects were included into the study, they were further dividend into the non-obese, obese, and morbidly obese cohorts. Dietary habits were established using the 7-day food records and selected anthropometric parameters were measured. Results: There were significant differences in genotype distributions of rs2274907 between the obese and morbidly obese cohorts (P = 0.01). In the multivariate modelling, the rs2274907 polymorphism expressed independent prediction role for the daily energy intake, independently on the age and gender (P = 0.03); the TT genotype associated with the lowest (7877 ± 2780 J/day) and the AA genotype with the highest (8764 ± 2467 J/day) average energy intake. The rs2274907 also significantly associated with the daily consumption of fat and proteins. Conclusion: This is, so far, the first study to investigate the polymorphisms in the omentin gene in a large population cohort of obese and non-obese individuals. Based on our results, the rs2274907 polymorphism is associated with the daily energy intake as well as daily intake of fat and protein.
VytisknoutZobrazeno: 7. 12. 2021 22:10