| SLÁVIK, Marek, Tetiana SHATOKHINA, Jiří ŠÁNA, Parwez AHMAD, Tomáš KAZDA, Iveta SELINGEROVÁ, Markéta HERMANOVÁ, Renata ČERVENÁ, Tomáš NOVOTNÝ, Petr BURKOŇ, Pavel SMILEK, Zuzana HORÁKOVÁ, Pavel ŠLAMPA a Ondřej SLABÝ. Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy. Head and Neck. Hoboken: Wiley, 2019, roč. 41, č. 4, s. 940-949. ISSN 1043-3074. Dostupné z: https://dx.doi.org/10.1002/hed.25533. |
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@article{1497636,
author = {Slávik, Marek and Shatokhina, Tetiana and Šána, Jiří and Ahmad, Parwez and Kazda, Tomáš and Selingerová, Iveta and Hermanová, Markéta and Červená, Renata and Novotný, Tomáš and Burkoň, Petr and Smilek, Pavel and Horáková, Zuzana and Šlampa, Pavel and Slabý, Ondřej},
article_location = {Hoboken},
article_number = {4},
doi = {http://dx.doi.org/10.1002/hed.25533},
keywords = {CD44; EGFR; immunohistochemistry; intensity-modulated radiotherapy; P16},
language = {eng},
issn = {1043-3074},
journal = {Head and Neck},
title = {Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy},
url = {http://dx.doi.org/10.1002/hed.25533},
volume = {41},
year = {2019}
}
TY - JOUR
ID - 1497636
AU - Slávik, Marek - Shatokhina, Tetiana - Šána, Jiří - Ahmad, Parwez - Kazda, Tomáš - Selingerová, Iveta - Hermanová, Markéta - Červená, Renata - Novotný, Tomáš - Burkoň, Petr - Smilek, Pavel - Horáková, Zuzana - Šlampa, Pavel - Slabý, Ondřej
PY - 2019
TI - Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy
JF - Head and Neck
VL - 41
IS - 4
SP - 940-949
EP - 940-949
PB - Wiley
SN - 10433074
KW - CD44
KW - EGFR
KW - immunohistochemistry
KW - intensity-modulated radiotherapy
KW - P16
UR - http://dx.doi.org/10.1002/hed.25533
L2 - http://dx.doi.org/10.1002/hed.25533
N2 - Background Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment. Methods p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients. Results In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup. Conclusion Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.
ER -
SLÁVIK, Marek, Tetiana SHATOKHINA, Jiří ŠÁNA, Parwez AHMAD, Tomáš KAZDA, Iveta SELINGEROVÁ, Markéta HERMANOVÁ, Renata ČERVENÁ, Tomáš NOVOTNÝ, Petr BURKOŇ, Pavel SMILEK, Zuzana HORÁKOVÁ, Pavel ŠLAMPA a Ondřej SLABÝ. Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy. \textit{Head and Neck}. Hoboken: Wiley, 2019, roč.~41, č.~4, s.~940-949. ISSN~1043-3074. Dostupné z: https://dx.doi.org/10.1002/hed.25533.
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