Sunitinib-Induced Elevation of Mean Corpuscular Volume
(MCV)-Exploring Its Possible Clinical Relevance in Cancer
Patients

J 2022

Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients

ŘIHÁČEK, Michal; Iveta SELINGEROVÁ; Ivo KOCÁK; Ilona KOCÁKOVÁ; Eva ŘIHÁČKOVÁ et al.

Základní údaje

Originální název

Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients

Autoři

ŘIHÁČEK, Michal; Iveta SELINGEROVÁ; Ivo KOCÁK; Ilona KOCÁKOVÁ; Eva ŘIHÁČKOVÁ; Dalibor VALÍK a Jaroslav ŠTĚRBA

Vydání

CURRENT ONCOLOGY, Basel, MDPI, 2022, 1198-0052

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00125957

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

sunitinib; mean corpuscular volume; MCV; toxicity

Štítky

14110211, 14110321, 14110512, 14110516, 14110616, 14110811, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 1. 2023 15:02, Mgr. Tereza Miškechová

Anotace

V originále

Sunitinib is a broad-spectrum multitargeted tyrosine kinase inhibitor mainly used as second-line therapy for non-resectable gastrointestinal stromal or first-line treatment option of metastatic renal cell carcinoma (mRCC), and as an “off-label” option in pediatric oncology. It has been previously reported that sunitinib elevates the mean corpuscular volume of erythrocytes (MCV) in treated subjects. The aim of this study was to assess time-dependent changes of this effect and evaluate its possible clinical relevance. In this study, 179 adult and 21 pediatric patients with solid tumors treated with sunitinib were retrospectively analyzed. The laboratory and treatment-related data were collected for each treatment period. The regression model with a broken-line relationship was used to fit time dependence of the MCV. In the adult group, the MCV was increasing during the first 21.6 weeks (median) of treatment in a median level of 99.8 fL, where it stabilized. MCV increase was faster in the patients who suffered from treatment-related adverse events (21.3 vs. 24.6 weeks, p = 0.010). In the pediatric cohort, the MCV dynamics were similar to adults. In conclusion, MCV changes during sunitinib treatment in pediatric and adult patients may be of clinical utility in monitoring sunitinib treatment course.

Návaznosti

MUNI/A/1427/2021, interní kód MU

Název: Personalizovaná léčba v dětské onkologii: na cestě k „liquid dynamic medicine“ a „N-of-1 clinical trials“

Investor: Masarykova univerzita, Personalizovaná léčba v dětské onkologii: na cestě k „liquid dynamic medicine“ a „N-of-1 clinical trials“

90125, velká výzkumná infrastruktura

Název: BBMRI-CZ III

90128, velká výzkumná infrastruktura

Název: CZECRIN III

Citovat

ŘIHÁČEK, Michal; Iveta SELINGEROVÁ; Ivo KOCÁK; Ilona KOCÁKOVÁ; Eva ŘIHÁČKOVÁ; Dalibor VALÍK a Jaroslav ŠTĚRBA. Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients. CURRENT ONCOLOGY. Basel: MDPI, 2022, roč. 29, č. 6, s. 4138-4147. ISSN 1198-0052. Dostupné z: https://doi.org/10.3390/curroncol29060330.

@article{1858785,
   author = {Řiháček, Michal and Selingerová, Iveta and Kocák, Ivo and Kocáková, Ilona and Řiháčková, Eva and Valík, Dalibor and Štěrba, Jaroslav},
   article_location = {Basel},
   article_number = {6},
   doi = {https://doi.org/10.3390/curroncol29060330},
   keywords = {sunitinib; mean corpuscular volume; MCV; toxicity},
   language = {eng},
   issn = {1198-0052},
   journal = {CURRENT ONCOLOGY},
   title = {Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients},
   url = {https://www.mdpi.com/1718-7729/29/6/330},
   volume = {29},
   year = {2022}
}

TY  - JOUR
ID  - 1858785
AU  - Řiháček, Michal - Selingerová, Iveta - Kocák, Ivo - Kocáková, Ilona - Řiháčková, Eva - Valík, Dalibor - Štěrba, Jaroslav
PY  - 2022
TI  - Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients
JF  - CURRENT ONCOLOGY
VL  - 29
IS  - 6
SP  - 4138-4147
EP  - 4138-4147
PB  - MDPI
SN  - 11980052
KW  - sunitinib
KW  - mean corpuscular volume
KW  - MCV
KW  - toxicity
UR  - https://www.mdpi.com/1718-7729/29/6/330
N2  - Sunitinib is a broad-spectrum multitargeted tyrosine kinase inhibitor mainly used as second-line therapy for non-resectable gastrointestinal stromal or first-line treatment option of metastatic renal cell carcinoma (mRCC), and as an “off-label” option in pediatric oncology. It has been previously reported that sunitinib elevates the mean corpuscular volume of erythrocytes (MCV) in treated subjects. The aim of this study was to assess time-dependent changes of this effect and evaluate its possible clinical relevance. In this study, 179 adult and 21 pediatric patients with solid tumors treated with sunitinib were retrospectively analyzed. The laboratory and treatment-related data were collected for each treatment period. The regression model with a broken-line relationship was used to fit time dependence of the MCV. In the adult group, the MCV was increasing during the first 21.6 weeks (median) of treatment in a median level of 99.8 fL, where it stabilized. MCV increase was faster in the patients who suffered from treatment-related adverse events (21.3 vs. 24.6 weeks, p = 0.010). In the pediatric cohort, the MCV dynamics were similar to adults. In conclusion, MCV changes during sunitinib treatment in pediatric and adult patients may be of clinical utility in monitoring sunitinib treatment course.
ER  -

ŘIHÁČEK, Michal; Iveta SELINGEROVÁ; Ivo KOCÁK; Ilona KOCÁKOVÁ; Eva ŘIHÁČKOVÁ; Dalibor VALÍK a Jaroslav ŠTĚRBA. Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients. \textit{CURRENT ONCOLOGY}. Basel: MDPI, 2022, roč.~29, č.~6, s.~4138-4147. ISSN~1198-0052. Dostupné z: https://doi.org/10.3390/curroncol29060330.

Přehled o publikaci