Methylenetetrahydrofolate reductase polymorphism, type II
diabetes mellitus, coronary artery disease and essential
hypertension in Czech population

J 2001

Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

BENEŠ, Petr; Kateřina KAŇKOVÁ; Jan MUŽÍK; Ladislav GROCH; Jaroslav BENEDÍK et. al.

Základní údaje

Originální název

Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

Název česky

Polymorfizmus v methylenetetrahydrofolatreduktaze, diabetes mellitus 2. typu, ICHS a esencialni hypertenze v Ceske populaci

Autoři

BENEŠ, Petr; Kateřina KAŇKOVÁ; Jan MUŽÍK; Ladislav GROCH; Jaroslav BENEDÍK; Lubomír ELBL; Lydie IZAKOVIČOVÁ HOLLÁ; Anna VAŠKŮ; Vladimír ZNOJIL a Jiří VÁCHA

Vydání

Molecular Genetics and Metabolism, San Diego, Academic Press, 2001, 1096-7192

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.345

Kód RIV

RIV/00216224:14110/01:00004148

Organizační jednotka

Lékařská fakulta

UT WoS

000169323700009

Klíčová slova anglicky

gene; polymorphism; MTHFR; CAD; hypertension; diabetes

Štítky

CAD, Diabetes, gene, Hypertension, MTHFR, polymorphism

Změněno: 17. 6. 2009 12:59, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.

Anotace

ORIG CZ

V originále

Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.

Česky

Studovali jsme asociaci polymorfizmu v methylenetetrahydrofolatreduktaze (MTHFR) s diabetem 2. typu, ICHS a esencialni hypertenzi v Ceske populaci.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BENEŠ, Petr; Kateřina KAŇKOVÁ; Jan MUŽÍK; Ladislav GROCH; Jaroslav BENEDÍK; Lubomír ELBL; Lydie IZAKOVIČOVÁ HOLLÁ; Anna VAŠKŮ; Vladimír ZNOJIL a Jiří VÁCHA. Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population. Molecular Genetics and Metabolism. San Diego: Academic Press, 2001, roč. 2, č. 73, s. 188-195. ISSN 1096-7192.

@article{360573,
   author = {Beneš, Petr and Kaňková, Kateřina and Mužík, Jan and Groch, Ladislav and Benedík, Jaroslav and Elbl, Lubomír and Izakovičová Hollá, Lydie and Vašků, Anna and Znojil, Vladimír and Vácha, Jiří},
   article_location = {San Diego},
   article_number = {73},
   keywords = {gene; polymorphism; MTHFR; CAD; hypertension; diabetes},
   language = {eng},
   issn = {1096-7192},
   journal = {Molecular Genetics and Metabolism},
   title = {Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population},
   volume = {2},
   year = {2001}
}

TY  - JOUR
ID  - 360573
AU  - Beneš, Petr - Kaňková, Kateřina - Mužík, Jan - Groch, Ladislav - Benedík, Jaroslav - Elbl, Lubomír - Izakovičová Hollá, Lydie - Vašků, Anna - Znojil, Vladimír - Vácha, Jiří
PY  - 2001
TI  - Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population
JF  - Molecular Genetics and Metabolism
VL  - 2
IS  - 73
SP  - 188
EP  - 188
PB  - Academic Press
SN  - 10967192
KW  - gene
KW  - polymorphism
KW  - MTHFR
KW  - CAD
KW  - hypertension
KW  - diabetes
N2  - Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.
ER  -

BENEŠ, Petr; Kateřina KAŇKOVÁ; Jan MUŽÍK; Ladislav GROCH; Jaroslav BENEDÍK; Lubomír ELBL; Lydie IZAKOVIČOVÁ HOLLÁ; Anna VAŠKŮ; Vladimír ZNOJIL a Jiří VÁCHA. Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population. \textit{Molecular Genetics and Metabolism}. San Diego: Academic Press, 2001, roč.~2, č.~73, s.~188-195. ISSN~1096-7192.

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