Two candidate gene polymorphisms in ADHD children: a
case-control study of catechol-o-methyltransferase (COMT) and
monoamine oxidase B (MAOB) genes

J 2006

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Vladimír MIKEŠ et. al.

Základní údaje

Originální název

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Název česky

Dva kandidátní DNA polymorfizmy u dětí s ADHD: asociační studie genů pro COMT a MAOB

Autoři

ŠTAIF, Radim (203 Česká republika), Ivana DRTÍLKOVÁ (203 Česká republika), Pavel THEINER (203 Česká republika), Renáta PITELOVÁ (203 Česká republika), Vladimír MIKEŠ (203 Česká republika) a Omar ŠERÝ (203 Česká republika, garant)

Vydání

Archives of Medical Science, Poland, Termedia Publishing House, 2006, 1734-1922

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/06:00018875

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

ADHD; COMT; MAOB; polymorphism; gene

Štítky

ADHD, COMT, gene, MAOB, polymorphism

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 2. 2008 17:35, prof. RNDr. Omar Šerý, Ph.D.

Anotace

ORIG CZ

V originále

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It is well known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD. Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the association between the studied groups. Results: There was no statistically significant difference in the genotype frequency of COMT (p=0.321) or MAOB (p=0.087) gene polymorphisms between the hyperactive group of boys and the control group of boys. Conclusion: Our study support the results of the previous studies: these two polymorphisms do not play the main role in the pathogenesis of ADHD.

Česky

Na souboru 118 chlapců s ADHD a 153 chlapců z kontrolní skupiny jsme nenalezli vztah mezi ADHD a polymorfizmy genů pro COMT a MAOB.

Návaznosti

NF6520, projekt VaV

Název: Klinické a molekulárně-biologické koreláty hyperkinetické poruchy v dětském věku

Investor: Ministerstvo zdravotnictví ČR, Klinické a molekulárně-biologické koreláty hyperkinetické poruchy v dětském věku

Citovat

ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Vladimír MIKEŠ a Omar ŠERÝ. Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes. Archives of Medical Science. Poland: Termedia Publishing House, 2006, roč. 2, č. 4, s. 235-239. ISSN 1734-1922.

@article{698628,
   author = {Štaif, Radim and Drtílková, Ivana and Theiner, Pavel and Pitelová, Renáta and Mikeš, Vladimír and Šerý, Omar},
   article_location = {Poland},
   article_number = {4},
   keywords = {ADHD; COMT; MAOB; polymorphism; gene},
   language = {eng},
   issn = {1734-1922},
   journal = {Archives of Medical Science},
   title = {Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes},
   volume = {2},
   year = {2006}
}

TY  - JOUR
ID  - 698628
AU  - Štaif, Radim - Drtílková, Ivana - Theiner, Pavel - Pitelová, Renáta - Mikeš, Vladimír - Šerý, Omar
PY  - 2006
TI  - Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes
JF  - Archives of Medical Science
VL  - 2
IS  - 4
SP  - 235-239
EP  - 235-239
PB  - Termedia Publishing House
SN  - 17341922
KW  - ADHD
KW  - COMT
KW  - MAOB
KW  - polymorphism
KW  - gene
N2  - Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It is well known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD. Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the association between the studied groups. Results: There was no statistically significant difference in the genotype frequency of COMT (p=0.321) or MAOB (p=0.087) gene polymorphisms between the hyperactive group of boys and the control group of boys. Conclusion: Our study support the results of the previous studies: these two polymorphisms do not play the main role in the pathogenesis of ADHD.
ER  -

ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Vladimír MIKEŠ a Omar ŠERÝ. Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes. \textit{Archives of Medical Science}. Poland: Termedia Publishing House, 2006, roč.~2, č.~4, s.~235-239. ISSN~1734-1922.

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