2008
Malondialdehyde as a prognostic parameter in squamous cell carcinoma of oral cavity and oropharynx
TOMANDL, Josef; Richard SALZMAN; Eva TOTHOVA; Lukáš PÁCAL; Kateřina KAŇKOVÁ et al.Základní údaje
Originální název
Malondialdehyde as a prognostic parameter in squamous cell carcinoma of oral cavity and oropharynx
Název česky
Malondialdehyd jako prognostický parametr u karcinomu dutiny ústní a hltanu
Autoři
Vydání
1. vyd. Praha, Sborník přednášek, od s. 126-126, 1 s. 2008
Nakladatel
Česká společnost pro biochemii a molekulární biologii
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
10600 1.6 Biological sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Označené pro přenos do RIV
Ne
Organizační jednotka
Lékařská fakulta
ISBN
80-86313-21-2
Klíčová slova anglicky
malondialdehyde; marker; head and neck squamous cell carcinoma
Štítky
Příznaky
Mezinárodní význam
Změněno: 21. 1. 2009 08:10, MUDr. Eva Tóthová
V originále
Oxidative stress and chronic inflammation certainly plays a significant role in head and neck carcinogenesis. Increased production of reactive oxygen species and metabolites such as malondialdehyde (MDA) a product of lipid peroxidation and cyclooxygenase activity may in turn induce DNA damage and mutations and, as a result, be carcinogenic. The aim of the study was to investigate relationships between MDA and the oncologic characteristics and survival parameters of patients with head and neck squamous cell carcinoma (HNSCC). We found significantly different level of MDA in T1-2 and T3-4 patients (p < 0.001) and strong correlation between MDA and T-stages (p < 0.0001). Besides, the level of MDA was significantly elevated in patients who manifested disease relapse during 3 years following the surgical tumor removal (p < 0.01). Our results confirm that advanced disease stages and recurrences in patients with HNSCC are accompanied by an increased oxidative stress.
Česky
Oxidative stress and chronic inflammation certainly plays a significant role in head and neck carcinogenesis. Increased production of reactive oxygen species and metabolites such as malondialdehyde (MDA) a product of lipid peroxidation and cyclooxygenase activity may in turn induce DNA damage and mutations and, as a result, be carcinogenic. The aim of the study was to investigate relationships between MDA and the oncologic characteristics and survival parameters of patients with head and neck squamous cell carcinoma (HNSCC). We found significantly different level of MDA in T1-2 and T3-4 patients (p < 0.001) and strong correlation between MDA and T-stages (p < 0.0001). Besides, the level of MDA was significantly elevated in patients who manifested disease relapse during 3 years following the surgical tumor removal (p < 0.01). Our results confirm that advanced disease stages and recurrences in patients with HNSCC are accompanied by an increased oxidative stress.
Návaznosti
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