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Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in ...

DUŠEK, Ladislav, Jitka ABRAHÁMOVÁ, Radek LAKOMÝ, Rostislav VYZULA, Jana KOPTÍKOVÁ, Tomáš PAVLÍK, Jan MUŽÍK a Daniel KLIMEŠ. Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in the Czech Republic. NEOPLASMA, SLOVAKIA: VEDA, SLOVAK ACAD SCIENCES, 2008, roč. 55, č. 4, s. 356-368. ISSN 0028-2685.
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Základní údaje
Originální název Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in the Czech Republic
Název česky Vícerozměrná analýza rizikových faktorů karcinomu varlat: případová studie pacientů v ČR
Název anglicky Multivariate analysis of risk factors for testicular cancer: a hospital-based case-control study in the Czech Republic
Autoři DUŠEK, Ladislav (203 Česká republika, garant), Jitka ABRAHÁMOVÁ (203 Česká republika), Radek LAKOMÝ (203 Česká republika), Rostislav VYZULA (203 Česká republika), Jana KOPTÍKOVÁ (203 Česká republika), Tomáš PAVLÍK (203 Česká republika), Jan MUŽÍK (203 Česká republika) a Daniel KLIMEŠ (203 Česká republika).
Vydání NEOPLASMA, SLOVAKIA, VEDA, SLOVAK ACAD SCIENCES, 2008, 0028-2685.
Další údaje
Originální jazyk čeština
Typ výsledku Článek v odborném periodiku
Obor 3.2 Clinical medicine
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.179
Kód RIV RIV/00216224:14110/08:00034569
Organizační jednotka Lékařská fakulta
UT WoS 000257128400014
Klíčová slova česky nádory varlat; rizikové faktory; případová studie
Klíčová slova anglicky testicular cancer; risk factors; case-control study
Štítky case-control study, risk factors, testicular cancer
Příznaky Recenzováno
Změnil Změnil: RNDr. Tomáš Pavlík, Ph.D., učo 52483. Změněno: 24. 6. 2009 15:17.
Anotace
Growing incidence of testicular cancer around the world stimulates research attempting to explain the trends. This study quantified the contribution of different types of potential risk factors for testicular germ-cell cancer (TGCC) with differentiation between seminoma and non-seminoma. A standardized questionnaire containing demographic data, pre- and perinatal factors, social, lifestyle and occupational parameters was prepared. The data file consists of n = 356 TGCCs (seminoma: n = 195; non-seminoma: n = 161) and n = 317 controls, frequency matched on age to cases. The following factors were significantly associated with the risk of TGCCs in univariate analyses (ORs): atrophic testis (5.3), smoking over 12 pack-yr (4.9), cryptorchidism (2.9), testicular trauma (2.0), birth weight under 3,000 g (1.6), low degree of education (3.0) in correlation with manual occupation (2.3) and finally, overall familial cancer history (1.5) and familial history of breast (1.8) and prostate cancer (3.9). On the other hand, maternal age over 20 yr (OR < 0.4) and moderate recreational sport activity (OR = 0.5) significantly reduced the risk of TGCCs. A significant risk was associated with cryptorchidism (OR = 2.9; 95% CI = 1.5-5.9) where orchidopexy was delayed after 5 yr of age (OR = 5.2; 95% CI = 1.5-18.1). Delayed orchidopexy was associated namely with the risk of seminomas (OR = 7.5; 95% CI = 2.1-26.7). Only some of the variables were retained in multivariate model for TGCCs as well as for histological subtypes (multivariate adjusted OR for all TGCCs): atrophic testis (5.9), family history of prostate cancer (4.8), cryptorchidism (3.8) and interaction term 'low degree of education & manual occupation' (3.0). Familial history of breast cancer elevated risk of TGCCs and of seminomas (OR: 2.01-2.18). Birth weight under 3,000 g was retained in a multivariate model for TGCCs with a borderline significance (OR = 1.67). We could not rule out any type of risk factors, as each one was significantly represented in the final multivariate models. Familial cancer history remained to be an influential risk factor, altogether with some lifestyle and occupational parameters. This suggests that both environmental exposures and genetic inheritance can play role in the moderation of the risk of TGCC.
Anotace anglicky
Growing incidence of testicular cancer around the world stimulates research attempting to explain the trends. This study quantified the contribution of different types of potential risk factors for testicular germ-cell cancer (TGCC) with differentiation between seminoma and non-seminoma. A standardized questionnaire containing demographic data, pre- and perinatal factors, social, lifestyle and occupational parameters was prepared. The data file consists of n = 356 TGCCs (seminoma: n = 195; non-seminoma: n = 161) and n = 317 controls, frequency matched on age to cases. The following factors were significantly associated with the risk of TGCCs in univariate analyses (ORs): atrophic testis (5.3), smoking over 12 pack-yr (4.9), cryptorchidism (2.9), testicular trauma (2.0), birth weight under 3,000 g (1.6), low degree of education (3.0) in correlation with manual occupation (2.3) and finally, overall familial cancer history (1.5) and familial history of breast (1.8) and prostate cancer (3.9). On the other hand, maternal age over 20 yr (OR < 0.4) and moderate recreational sport activity (OR = 0.5) significantly reduced the risk of TGCCs. A significant risk was associated with cryptorchidism (OR = 2.9; 95% CI = 1.5-5.9) where orchidopexy was delayed after 5 yr of age (OR = 5.2; 95% CI = 1.5-18.1). Delayed orchidopexy was associated namely with the risk of seminomas (OR = 7.5; 95% CI = 2.1-26.7). Only some of the variables were retained in multivariate model for TGCCs as well as for histological subtypes (multivariate adjusted OR for all TGCCs): atrophic testis (5.9), family history of prostate cancer (4.8), cryptorchidism (3.8) and interaction term 'low degree of education & manual occupation' (3.0). Familial history of breast cancer elevated risk of TGCCs and of seminomas (OR: 2.01-2.18). Birth weight under 3,000 g was retained in a multivariate model for TGCCs with a borderline significance (OR = 1.67). We could not rule out any type of risk factors, as each one was significantly represented in the final multivariate models. Familial cancer history remained to be an influential risk factor, altogether with some lifestyle and occupational parameters. This suggests that both environmental exposures and genetic inheritance can play role in the moderation of the risk of TGCC.
Návaznosti
MSM0021622412, záměrNázev: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Akronym: INCHEMBIOL)
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumné záměry
VytisknoutZobrazeno: 26. 4. 2019 14:18

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