Role of thiamine status and genetic variability in
transketolase and other pentose phosphate cycle enzymes in the
progression of diabetic nephropathy

J 2010

Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy

PÁCAL, Lukáš; Josef TOMANDL; Jan SVOJANOVSKÝ; Darja KRUSOVÁ; Soňa ŠTĚPÁNKOVÁ et al.

Základní údaje

Originální název

Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy

Autoři

Vydání

Nephrology Dialysis Transplantation, Velká Británie, Oxford University Press, 2010, 0931-0509

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.564

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00040785

Organizační jednotka

Lékařská fakulta

UT WoS

000289309400018

Klíčová slova anglicky

diabetic nephropathy; pentose phosphate pathway; thiamine; thiamine deficiency; transaldolase; transketolase

Změněno: 5. 12. 2012 09:53, prof. MUDr. Kateřina Kaňková, Ph.D.

Anotace

V originále

Results of this study indicate dysfunction/deficit of intracellular active form of thiamine in diabetics which serves as a cofactor for transketolase - the key enzyme of pentose phosphate pathway which is considered one of the few potentially counterbalancing pathways opposing hyperglycemia effects. Ascertained functional thiamine deficiency in diabetes, especially when accompanied with advanced renal disease, could be potentially a critical abnormality influencing the activity of pentose phosphate pathway, development if hyperglycemia-mediated damage and diabetic complications and also target of event. pharmacologic interventions.

Návaznosti

NR9443, projekt VaV

Název: Genetická variabilita enzymů pentózového cyklu jako faktor modulující nástup a progresi diabetické nefropatie

Investor: Ministerstvo zdravotnictví ČR, Genetická variabilita enzymů pentózového cyklu jako faktor modulující nástup a progresi diabetické nefropatie

Citovat

PÁCAL, Lukáš; Josef TOMANDL; Jan SVOJANOVSKÝ; Darja KRUSOVÁ; Soňa ŠTĚPÁNKOVÁ; Jitka ŘEHOŘOVÁ; Jindřich OLŠOVSKÝ; Jana BĚLOBRÁDKOVÁ; Veronika TANHÄUSEROVÁ; Marie TOMANDLOVÁ; Jan MUŽÍK a Kateřina KAŇKOVÁ. Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy. Nephrology Dialysis Transplantation. Velká Británie: Oxford University Press, 2010, roč. 26, č. 4, s. 1229-1236, 4 s. ISSN 0931-0509.

@article{894948,
   author = {Pácal, Lukáš and Tomandl, Josef and Svojanovský, Jan and Krusová, Darja and Štěpánková, Soňa and Řehořová, Jitka and Olšovský, Jindřich and Bělobrádková, Jana and Tanhäuserová, Veronika and Tomandlová, Marie and Mužík, Jan and Kaňková, Kateřina},
   article_location = {Velká Británie},
   article_number = {4},
   keywords = {diabetic nephropathy; pentose phosphate pathway; thiamine; thiamine deficiency; transaldolase; transketolase},
   language = {eng},
   issn = {0931-0509},
   journal = {Nephrology Dialysis Transplantation},
   title = {Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy},
   volume = {26},
   year = {2010}
}

TY  - JOUR
ID  - 894948
AU  - Pácal, Lukáš - Tomandl, Josef - Svojanovský, Jan - Krusová, Darja - Štěpánková, Soňa - Řehořová, Jitka - Olšovský, Jindřich - Bělobrádková, Jana - Tanhäuserová, Veronika - Tomandlová, Marie - Mužík, Jan - Kaňková, Kateřina
PY  - 2010
TI  - Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy
JF  - Nephrology Dialysis Transplantation
VL  - 26
IS  - 4
SP  - 1229-1236
EP  - 1229-1236
PB  - Oxford University Press
SN  - 09310509
KW  - diabetic nephropathy
KW  - pentose phosphate pathway
KW  - thiamine
KW  - thiamine deficiency
KW  - transaldolase
KW  - transketolase
N2  - Results of this study indicate dysfunction/deficit of intracellular active form of thiamine in diabetics which serves as a cofactor for transketolase - the key enzyme of pentose phosphate pathway which is considered one of the few potentially counterbalancing pathways opposing hyperglycemia effects. Ascertained functional thiamine deficiency in diabetes, especially when accompanied with advanced renal disease, could be potentially a critical abnormality influencing the activity of pentose phosphate pathway, development if hyperglycemia-mediated damage and diabetic complications and also target of event. pharmacologic interventions.
ER  -

PÁCAL, Lukáš; Josef TOMANDL; Jan SVOJANOVSKÝ; Darja KRUSOVÁ; Soňa ŠTĚPÁNKOVÁ; Jitka ŘEHOŘOVÁ; Jindřich OLŠOVSKÝ; Jana BĚLOBRÁDKOVÁ; Veronika TANHÄUSEROVÁ; Marie TOMANDLOVÁ; Jan MUŽÍK a Kateřina KAŇKOVÁ. Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy. \textit{Nephrology Dialysis Transplantation}. Velká Británie: Oxford University Press, 2010, roč.~26, č.~4, s.~1229-1236, 4 s. ISSN~0931-0509.

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