ZLBC0321s Biochemistry I - seminar

Faculty of Medicine
autumn 2025
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
doc. PharmDr. Jiří Kos, Ph.D. (seminar tutor)
Ing. Bc. Hana Logerová, Ph.D. (seminar tutor)
doc. Mgr. Ondřej Peš, Ph.D. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Iva Audy (assistant)
doc. RNDr. Jiří Dostál, CSc. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
ZLBC0321s/21: Fri 8:00–9:40 A16/213, M. Králíková
ZLBC0321s/22: Fri 8:00–9:40 A16/213, M. Králíková
ZLBC0321s/23: Fri 14:00–15:40 A16/213, H. Logerová, O. Peš
ZLBC0321s/24: Fri 14:00–15:40 A16/213, H. Logerová, O. Peš
Prerequisites (in Czech)
ZLLC011p Med Chem, Dent Mat - lect && ZLBF0222p Med.Physics and Inf. II - lect && ZLBI0222p Biology II-lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The aim of the course is to practice basic metabolic processes and pathways occurring at the cellular level.
Understanding these processes is the basis for understanding metabolism at the tissue and organ level, which is studied in the follow-up course Biochemistry II.
Learning outcomes
At the end of the course, students will:
- understand the meaning of basic chemical terms (pH, osmolality, electrolyte, buffer, etc.) and apply this knowledge when describing the properties of body fluids.
- discuss the properties and function of enzymes
- describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism and their relationships.
- understand the principles of energy production, utilization and deposition at the cellular level.
- explain the function of cell membranes and the principle of compartmentalization at the cellular level, and the transport processes on the membrane.
- describe protein synthesis, starting with replication, transcription, translation, and post-translational modifications. Understand the relationship between protein structure and function.
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
- discuss the principles of some diseases at the molecular level.
Key topics
  • Introduction to cellular metabolism. Cell membranes, membrane transport.
  • Enzymes, kinetics, inhibition.
  • Cofactors, relationship to vitamins.
  • Citrate cycle. Respiratory chain and aerobic phosphorylation. ROS.
  • Carbohydrate digestion. Glucose transport into cells.
  • Glycolysis. Gluconeogenesis. Glycogen metabolism.
  • Lipid digestion. Fatty acid and ketone body metabolism.
  • PUFA synthesis. Triacylglycerol and phospholipid synthesis.
  • Cholesterol and bile acid metabolism. Lipid peroxidation, eicosanoids.
  • Protein digestion. Overview of protein metabolism. General features of amino acid metabolism.
  • Urea synthesis.
  • Important reactions in amino acid conversions.
  • Heme biosynthesis. Structure and function of hemoglobin.
  • Replication, transcription.
Study resources and literature
    required literature
  • Interaktivní osnova v IS MU.
  • LEDVINA, Miroslav; Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • LEDVINA, Miroslav; Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, Strana 275. ISBN 9788024647494. info
    recommended literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
  • FERRIER, Denise R. Lippincott's illustrated Q&A review of biochemistry. Seventh edition. Wolters Kluwer, 2017. ISBN 9781496344496. info
Approaches, practices, and methods used in teaching
Active practicing and discussion.
Method of verifying learning outcomes and course completion requirements
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Listed among pre-requisites of other courses
Teacher's information
Detailed information on the teaching and completion of the course is given in the Study Materials in IS MU.
The course is also listed under the following terms autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2025/ZLBC0321s