ZLBI0222p Biology II - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught online.
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
Mgr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
doc. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Jana Růžičková (assistant)
Mgr. Kateřina Straková, Ph.D. (alternate examiner)
Guaranteed by
doc. MUDr. Iva Slaninová, Ph.D.
Department of Biology - Theoretical Departments - Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology - Theoretical Departments - Faculty of Medicine
Prerequisites
ZLBI0121c Biology I - pract.
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended for studying before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the mechanisms of cancer development
- understanding the complex taking place during human embryonic development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Learning outcomes
After completing the course, the student will be able to:
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- explain the effects of some therapies with emphasis on modern medicine (molecular therapies of cancer)
- explain the elementary processes taking place during the development of a human body
- express the basic coherence between malfunction in these processes and developmental defects
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome composition
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics, bioinformatics)
Syllabus
  • DNA damage and repair – from molecular mechanisms to clinical significance
  • Introduction to cancer biology
  • Oncogenes and oncoviruses in cancer transformation
  • Tumour suppressor genes and their significance for diagnostics and therapy
  • The paradigm of cancer stem cells and implications for anti-cancer therapies
  • Gene therapy – targets and strategies of molecular therapies
  • Stem cells and tissue engineering – prospects of regenerative medicine
  • From a single cell to human I – introduction to developmental biology
  • From a single cell to human II – molecular basis of mammalian development in health and disease
  • The human genome, genomics and bioinformatics in current biomedicine
  • Human microbiome
  • Modern approaches in studying macromolecules and their use in current biomedicine
Literature
    required literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004. xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007. 182 stran. ISBN 9788072624492. info
    not specified
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014. xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013. 1 online r. ISBN 9781118689028. info
Teaching methods
lecture every week
Assessment methods
Lecture attendance is optional. The course of Biology II builds on the knowledge gained from Biology I, and is completed with a written examination test taken on computers. The test contains questions based on the topics discussed in the lectures and practices of both semesters. The students are expected to be able to autonomously solve assigned problems and to derive the solutions using their own thinking – based on the theory discussed during both semesters and supplemented by the recommended reading. The test contains 60 questions in total; at least 30 points are needed to pass.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

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Teacher's information
https://is.muni.cz/auth/el/1411/jaro2020/ZLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020.
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