ZLBC0422s Biochemistry II - seminar

Faculty of Medicine
spring 2026
Extent and Intensity
0/3/0. 2 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
doc. PharmDr. Jiří Kos, Ph.D. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Iva Audy (assistant)
doc. RNDr. Jiří Dostál, CSc. (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: RNDr. Hana Paulová, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
( ZLBC0321s Biochemistry I - seminar || ZLBC0221s Biochemistry I - seminar ) && ZLFY0321s Physiology I - sem. && ZLBI0222p Biology II-lect.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to Biochemistry lecture (ZLBC0422p). The knowledge of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome)are thoroughly practiced during Biochemistry seminars.
Learning outcomes
The student will be able to:
- explain the interrelationships between nutrient metabolism under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discussing their relationship to diseases.
- understand and discuss the principles of maintaining homeostasis and acid-base balance in the  organism, including dealing with model situations.
- present body fluid composition and disorders in relation to principles of homeostasis.
- explain the principles of metabolic regulation at all levels.
Syllabus
  • Factors influencing laboratory tests, interpretation of results. Diagnostic accuracy.
  • Enzymes in diagnostics.
  • Blood glucose homeostasis, metabolic disorders in diabetes mellitus.
  • Protein quality. Protein and amino acid transformations in different states.
  • Blood plasma lipids. Lipoprotein transformations. Cholesterol transport.
  • Nutrient transformations in different states. Energy balance, obesity, metabolic syndrome.
  • Role of the liver in metabolism of nutrients, hormones and vitamins. Catabolism of heme.
  • Metabolism of iron and copper.
  • Biotransformation of xenobiotics. Alcohol metabolism.
  • Water homeostasis, Na+ and K+. Regulation of osmolality and volemia. Disorders of water homeostasis.
  • Acid-base balance and disorders. Transport of O2 and CO2.
  • Kidney functions.
  • Receptors and signal transduction.
  • Steroid and thyroid hormones.
  • Biochemistry of muscle activity.
  • Metabolism of calcium, magnesium, phosphorus, fluorine and iodine.
  • Metabolism of hard tissues.
  • Biochemistry of oral cavity.
Literature
    required literature
  • Interaktivní osnova v IS MU.
  • LEDVINA, Miroslav; Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
    recommended literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
Teaching methods
Seminary course. Class discussions on assigned topics.
Assessment methods
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught every week.
General note: Úspěšné ukončení předmětu je podmínkou přístupu ke zkoušce v předmětu ZLBC0422p.
Listed among pre-requisites of other courses
Teacher's information
Detailed information on the teaching and completion of the course is given in the Study Materials in IS MU.
Consultation is possible after a personal arrangement with the teacher.
The course is also listed under the following terms spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/spring2026/ZLBC0422s