ZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2026
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Iva Audy (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
ZLFY0321s Physiology I - sem. && ZLBI0222p Biology II-lect. && ( ZLBC0321s Biochemistry I - seminar || ZLBC0221s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student will be able to:
- explain the interrelationships between nutrient metabolism under different states of the body.
- describe the metabolic characteristics of major organs and tissues and major disorders, discussing their relationship to diseases.
- understand and discuss the principles of maintaining homeostasis and acid-base balance in the organism, including dealing with model situations.
- describe the composition of body fluids and its disorders in relation to principles of homeostasis.
- explain the principles of metabolic regulation at all levels.
Syllabus
  • Blood plasma lipids. Lipoprotein transformations.
  • Nutrient metabolism in various states.
  • Biochemical functions of the liver, role in iron metabolism.
  • Heme catabolism.
  • Biotransformation of xenobiotics, cytochromes P450. Metabolism of ethanol.
  • Homeostasis of water, Na+ and K+. Plasma osmolality.
  • Acid-base balance, buffer systems. Transport of O2 and CO2 in blood.
  • Kidney function in homeostasis.
  • Regulation of metabolism. General mechanisms of cell signalling.
  • Biochemistry of nervous tissue, processes at synapses.
  • Metabolism of calcium, phosphorus, fluorine.
  • Extracellular matrix. Hard tissues, mineralization.
  • Saliva and oral homeostasis, the influence of diet. Dental plaque.
  • Vascular endothelium. Hemocoagulation, anticoagulation mechanisms.
  • Biochemistry of blood elements. Blood plasma proteins.
Literature
    required literature
  • LEDVINA, Miroslav; Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • Interaktivní osnova v IS MU.
  • Doporučovaná literatura z lékařské fyziologie v předmětu ZLFY0422p.
    recommended literature
  • FERRIER, Denise R. Biochemistry. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2014, 552 s. ISBN 9781451175622. info
  • MURRAY, Robert K.; David A. BENDER; Kathleen M. BOTHAM; Peter J. KENNELLY; Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • VASUDEVAN, DM; S SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Prvé slovenské vydanie. Bratislava: Balneotherma, 2015, 670 pp. ISBN 978-80-970156-8-8. info
  • LIEBERMAN, Michael; Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
Teaching methods
Lectures
Assessment methods
Oral exam.
The student draws questions from Biochemistry I and Biochemistry II.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů ZLBC0422s.
The course is taught annually.
The course is taught every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
Information on the examination, including the topics included in the examination, is available in the IS MU Study Materials.
The course is also listed under the following terms spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2026, recent)
  • Permalink: https://is.muni.cz/course/med/spring2026/ZLBC0422p