ZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Taught in person.
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: prof. RNDr. Eva Táborská, CSc.
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Mon 12:00–12:50 B11/334
Prerequisites (in Czech)
ZLFY0321s Physiology I - sem. && ZLBI0222p Biology II-lect. && ( ZLBC0321s Biochemistry I - seminar || ZLBC0221s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
  • Plasma lipids. Lipoprotein metabolism.
  • Nutrient metabolism in different conditions.
  • Biochemical functions of the liver. Iron metabolism. Heme catabolism.
  • Membrane and intracellular receptors. General mechanisms of action of hormones and neurotransmitters.
  • Nervous tissue metabolism. Neurotransmitters, synapses.
  • Homeostasis of water, Na + and K  + ions. Regulation of osmolality and volemia.
  • Acid-base balance. Transport O  2 and CO 2 through blood. Buffer bases.
  • Biochemical functions of the kidneys. Renal filtration function. Tubular resorption and secretion.
  • Metabolism of calcium, magnesium, phosphates, fluorine and iodine.
  • Extracellular matrix. Bone metabolism, calcification of bones, dentin, enamel and cement.
  • Saliva and biochemical aspects of oral homeostasis. Plaque metabolism. The effect of diet on the condition of the oral cavity and teeth.
  • Major proteins of blood plasma. Haemocoagulation, fibrinolysis.
  • Vascular endothelium. Biochemistry of blood elements.
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020. 269 stran. ISBN 9788024647487. info
  • Supplementary materials: https://is.muni.cz/auth/el/med/jaro2022/ZLBC0422s/um/
    recommended literature
  • FERRIER, Denise R. Biochemistry. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2014. 552 s. ISBN 9781451175622. info
  • GANONG, William F. Přehled lékařské fyziologie. 20. vyd. Praha: Galén, 2005. xx, 890. ISBN 8072623117. info
  • COSTANZO, Linda S. Physiology. Seventh edition. Philadelphia, PA: Elsevier, 2022. x, 518. ISBN 9780323793339. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012. 498 pp. ISBN 978-80-247-2977-0. info
Teaching methods
Assessment methods
Oral exam - students will draw three questions from Biochemistry I and Biochemistry II.
Language of instruction
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

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Teacher's information
The basic concepts and topics included in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms spring 2020, spring 2021.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/spring2022/ZLBC0422p