ZLBC041p Biochemistry II - lecture

Faculty of Medicine
spring 2020
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
PharmDr. Katarína Kostolanská (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Monika Šudáková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: Monika Šudáková
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Fri 11:00–11:50 B11/234, except Fri 3. 4., except Fri 24. 4., except Fri 15. 5., except Fri 22. 5.
Prerequisites (in Czech)
ZLLC011p Medical Chemistry,DM - lecture && ZLBF011p Med.Physics and Informat.-lect && ZLBI0222p Biology II-lect. && ZLBC0221s Biochemistry I - seminar && ZLFY0321c Physiology I - pract. && ZLFY0321s Physiology I - sem.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolism of chylomicrons, VLDL, HDL. --- The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, DM). --- The metabolic functions of the liver. Catabolism of hemoglobin, bilirubin metabolism. Metabolism of iron. --- Biotransformation of xenobiotics, typical reactions, cytochrome P450. Metabolism of ethanol. --- Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors. --- Nerve cells. Neurosecretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors. --- Body water, the movement of water between ECF and ICF, water excretion. Ionic composition of blood plasma, gradients of Na+ and K+ across cell membranes. Osmolality of ECF, regulation of the ECF osmolality and volume, fluid and electrolyte balance. --- Transport of O2 and CO2. Metabolic pathways producing/consumpting H+ ions. Buffer bases of blood, blood plasma (concentrations of components), ICF, the parameters of acid-base status. The role of the lung, the kidney, and the liver in maintaining acid-base balance. --- Normal renal functions. Glomerular filtration. Tubular resorption and secretion. --- Metabolism of calcium, magnesium, phosphates, fluorides, and iodine. Hormones involved in their metabolism. --- The extracellular matrix. Mineralisation of hard tissues, regulation. Composition of bones, dentine, enamel, and cement. --- Saliva and biochemical aspects of oral homeostasis. Plaque formation and metabolism. Influence of nutrition on oral health. --- The major proteins of blood plasma. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis. --- Endothelial cells. Biochemistry of blood cells.
    required literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012. 498 pp. ISBN 978-80-247-2977-0. info
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012. xii, 730. ISBN 9788072629077. info
  • Podklady k přednáškám v IS.
    recommended literature
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015. 669 stran. ISBN 9788097015688. info
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (ZLBC041c and ZLBC041c).
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam. The examination has writen and oral part. The test consists of 25 questions and is solved on computers in the computer room of Department of Biochemistry (personal university ID /UCO/ and pass-word for IS MUNI is necessary for entrance to the test): As a rule, 10 questions are from practical exercises. Remaining 15 questions cover essential knowledge ranging over all studied topics. Only those students who gain 14 correct answers at a minimum will be permitted to sit for the oral examination. The oral part of examination Students select three questions and have about 30 minutes for the written preparation. They should summarize their answers as concisely and accurately as possible. It is recommended to follow these items: - to write a brief synopsis emphasizing the main ideas - to draw metabolic pathways in structural formulas with a short comment - where appropriate, to draw a picture A good and concise preparation reflects the students’ knowledge and understanding the biochemistry and will be considered in the final classification.
Language of instruction
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Biochemie I.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019.
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