ZLFA0621c Pharmacology I - practice

Faculty of Medicine
spring 2021
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Learning outcomes
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Syllabus
  • Pharmacology - practical courses

    Dentistry

    Spring semester 2020

  • /1/
  • INTRODUCTION TO THE STUDY OF PHARMACOLOGY
  • Contents of the study of Pharmacology, contents and organization of theoretical and practical courses and lectures, required and recommended textbooks. The conditions for granting the credit. Pharmacology - definition, basic terminology, subspecializations, drug nomenclature. Introduction to the prescription terminology. Classification of drug preparations. Pharmacopoea, Pharmacopoea Bohemica.
  • INTRODUCTION TO THE PHARMACOKINETICS
  • Transport of drugs across biological barriers. Basic pharmacokinetic processes. Pharmacokinetic parameters. Pharmacokinetics of single and repeated intravascular and extravascular drug administration. Therapeutic drug monitoring (therapeutic monitoring of drug plasmatic concentrations).
  • /2/
  • GENERAL RULES OF THE DRUG PRESCRIPTION
  • Medical prescription and its essentials. Prescription of drugs. Legislation of drug prescription. Work with various handbooks and databases (SÚKL database, Pharmindex, AISLP etc.). Prescription and provisions of narcotic and psychotropic substances.
  • PRESCRIPTION OF READY MADE PREPARATIONS. ROUTES OF DRUG ADMINISTRATION
  • Prescription ready made preparations - practice. Routes of drug administration - overview.
  • /3/
  • DRUG DOSAGE FORMS - OVERVIEW (SOLID, FLUID, SOFT AND MELTING, GASEOUS DRUG DOSAGE FORMS
  • Prescriptions of selected drug forms (solid drug dosage forms – powders, capsules, tablets, suppositories; fluid drug dosage forms - solutions for rubbing, compresses and lavages, solutions and drops for oral administration; soft and melting drug dosage forms – ointments, creams, pastes, gels and other preparations for application to the skin and mucous membranes; gaseous drug dosage forms - drugs for inhalations and medical gases).
  • SELECTED DRUG DOSAGE FORMS USED IN DENTISTRY
  • Special prescription of individually prepared drugs used in dentistry (mucoadhesive pastes, solutions, suspensions, gels, ointments, pastes).
  • /4/
  • PRESCRIPTION TEST (PRESCRIPTION OF INDIVIDUALLY PREPARED AND READY MADE PREPARATIONS)
  • INTRODUCTION TO PHARMACODYNAMICS
  • Mechanisms of drug effects - non-specific and specific (direct and indirect)
  • PHARMACOLOGY OF PERIPHERAL NERVOUS SYSTEM - introduction
  • Terminology, neurotransmissions in peripheral nervous system, adrenergic and cholinergic receptors, agonists and antagonists. Functional importance and possibilities of pharmacological affection of sympathetic and parasympathetic system.
  • NORADRENERGIC (SYMPATHETIC) DRUGS
  • Receptors of noradrenergic (sympathetic) system, pharmacology of drugs activating and blocking noradrenergic (sympathetic) system.
  • /5/
  • MULTIPLE CHOICE FINAL (CREDIT) TEST OF PHARMACOLOGY (MCHQ - topics lessons from days 1 to 4)
  • CHOLINERGIC (PARASYMPATHETIC) DRUGS
  • Receptors of cholinergic (parasympathetic) system, pharmacology of drugs activating and blocking cholinergic (parasympathetic) system.
  • H1 - ANTIHISTAMINES, DRUGS USED FOR THE TREATMENT OF BRONCHIAL OBSTRUCTION
  • Effects of histamine, the possibilities of histamine effects antagonizing. Histamine receptors. Classification and overview of H1 - antihistamines. Sympathomimetics and parasympatholytics used in diseases with bronchial obstruction.
  • CREDITS
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010. 96 pp. ISSN 1801-6103. URL info
  • For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
    recommended literature
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. info
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
    not specified
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
  • ZELENKOVÁ, Olga and Alexandra ŠULCOVÁ. Speciální stomatologická receptura pro praktická cvičení z farmakologie (Special stomatological prescriptions for practicals in pharmacology). 2. přepracované vydání. Brno: Masarykova univerzita v Brně, 2000. 30 pp. ISBN 80-210-2433-X. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Český lékopis 2009. Praha: Grada, 2011. 1 DVD-ROM. ISBN 8594049240180. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • http://portal.med.muni.cz/clanek-652-behavioralni-metody-v-neuropsychofarmakologii.html ruda 2016
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • ŠULCOVÁ, Alexandra. Poznámky k přednáškám z farmakologie. 1. vyd. Brno: Masarykova univerzita, 1993. 97 s. ISBN 80-210-0640-4. info
Teaching methods
Practicals, the teaching process of include theoretical setting up as well as practical training of knowledge and skills stated in Syllabus. Included are also individual work with specific pharmacological softwares and homeworks on the selected topics, presented and discussed afterward in class.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 2 written tests: 1) on drug prescription + translation of selected prescription expressions into Latin (assessed individually by the teacher), 2) the multiple-choice test on knowledge of topics taught. More than half correctly answered questions (usually from 15) are required.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020.
  • Enrolment Statistics (spring 2021, recent)
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