ZLFA0621c Pharmacology I - practice

Faculty of Medicine
spring 2022
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Taught in person.
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
PharmDr. Adéla Bártová (seminar tutor)
MVDr. Eva Dražanová, Ph.D. (seminar tutor)
PharmDr. Tomáš Hammer (seminar tutor)
Mgr. Mária Hricková (seminar tutor)
PharmDr. Eva Klásková (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Mgr. Marta Vyoralová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Timetable of Seminar Groups
ZLFA0621c/21: Mon 14. 3. 10:00–12:30 A19/326, Tue 15. 3. 10:00–12:30 A19/326, Wed 16. 3. 10:00–12:30 A19/326, Thu 17. 3. 10:00–12:30 A19/326, Fri 18. 3. 10:00–12:30 A19/326, Mon 21. 3. 10:00–12:30 A19/326, Tue 22. 3. 10:00–12:30 A19/326, Wed 23. 3. 10:00–12:30 A19/326, Thu 24. 3. 10:00–12:30 A19/326, Fri 25. 3. 10:00–12:30 A19/326
ZLFA0621c/22: Mon 28. 3. 7:30–10:00 A19/326, Tue 29. 3. 7:30–10:00 A19/326, Wed 30. 3. 7:30–10:00 A19/326, Thu 31. 3. 7:30–10:00 A19/326, Fri 1. 4. 7:30–10:00 A19/326, Mon 11. 4. 10:00–12:30 A19/326, Tue 12. 4. 10:00–12:30 A19/326, Wed 13. 4. 10:00–12:30 A19/326, Thu 14. 4. 10:00–12:30 A19/326
ZLFA0621c/23: Mon 11. 4. 7:30–10:00 A19/326, Tue 12. 4. 7:30–10:00 A19/326, Wed 13. 4. 7:30–10:00 A19/326, Thu 14. 4. 7:30–10:00 A19/326, Mon 25. 4. 10:00–12:30 A19/326, Tue 26. 4. 10:00–12:30 A19/326, Wed 27. 4. 10:00–12:30 A19/326, Thu 28. 4. 10:00–12:30 A19/326, Fri 29. 4. 10:00–12:30 A19/326
Prerequisites (in Czech)
ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Learning outcomes
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Syllabus
  • Pharmacology - practical courses

    Dentistry

    Spring semester 2022

    1st week
  • /1/MONDAY
  • INTRODUCTION TO THE STUDY OF PHARMACOLOGY
  • Contents of the study of Pharmacology, contents and organization of theoretical and practical courses and lectures, required and recommended textbooks. The conditions for granting the credit. Pharmacology - definition, basic terminology, subspecializations, drug nomenclature. Introduction to the prescription terminology. Classification of drug preparations. Pharmacopoea, Pharmacopoea Bohemica.
  • /2/TUESDAY
  • INTRODUCTION TO THE PHARMACOKINETICS
  • Transport of drugs across biological barriers. Basic pharmacokinetic processes. Pharmacokinetic parameters. Pharmacokinetics of single and repeated intravascular and extravascular drug administration. Therapeutic drug monitoring (therapeutic monitoring of drug plasmatic concentrations).
  • /3/WEDNESDAY
  • GENERAL RULES OF THE DRUG PRESCRIPTION
  • Medical prescription and its essentials. Prescription of drugs. Legislation of drug prescription. Work with various handbooks and databases (SÚKL database, Pharmindex, AISLP etc.). Prescription and provisions of narcotic and psychotropic substances.
  • /4/THURSDAY
  • PRESCRIPTION OF READY MADE PREPARATIONS. ROUTES OF DRUG ADMINISTRATION
  • Prescription ready made preparations - practice. Routes of drug administration - overview.
  • /5/FRIDAY
  • DRUG DOSAGE FORMS - OVERVIEW (SOLID, FLUID, SOFT AND MELTING, GASEOUS DRUG DOSAGE FORMS
  • Prescriptions of selected drug forms (solid drug dosage forms – powders, capsules, tablets, suppositories; fluid drug dosage forms - solutions for rubbing, compresses and lavages, solutions and drops for oral administration; soft and melting drug dosage forms – ointments, creams, pastes, gels and other preparations for application to the skin and mucous membranes; gaseous drug dosage forms).
  • 2nd week
  • /6/MONDAY
  • SELECTED DRUG DOSAGE FORMS USED IN DENTISTRY
  • Special prescription of individually prepared drugs used in dentistry (mucoadhesive pastes, solutions, suspensions, gels, ointments, pastes).
  • PRESCRIPTION TEST (PRESCRIPTION OF INDIVIDUALLY PREPARED AND READY MADE PREPARATIONS)
  • /7/TUESDAY
  • INTRODUCTION TO PHARMACODYNAMICS
  • Mechanisms of drug effects - non-specific and specific (direct and indirect)
  • PHARMACOLOGY OF PERIPHERAL NERVOUS SYSTEM - introduction
  • Terminology, neurotransmissions in peripheral nervous system, adrenergic and cholinergic receptors, agonists and antagonists. Functional importance and possibilities of pharmacological affection of sympathetic and parasympathetic system.
  • /8/WEDNESDAY
  • NORADRENERGIC (SYMPATHETIC) DRUGS
  • Receptors of noradrenergic (sympathetic) system, pharmacology of drugs activating and blocking noradrenergic (sympathetic) system.
  • /9/THURSDAY
  • CHOLINERGIC (PARASYMPATHETIC) DRUGS
  • Receptors of cholinergic (parasympathetic) system, pharmacology of drugs activating and blocking cholinergic (parasympathetic) system.
  • /10/FRIDAY
  • H1 - ANTIHISTAMINES, DRUGS USED FOR THE TREATMENT OF BRONCHIAL OBSTRUCTION
  • Effects of histamine, the possibilities of histamine effects antagonizing. Histamine receptors. Classification and overview of H1 - antihistamines. Sympathomimetics and parasympatholytics used in diseases with bronchial obstruction.
  • MULTIPLE CHOICE FINAL (CREDIT) TEST OF PHARMACOLOGY (MCHQ - topics lessons from days 1 to 9)
  • CREDITS
Literature
    required literature
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN and H. P. RANG. Rang and Dale's pharmacology. Ninth edition. Edinburgh: Elsevier, 2020. xvi, 789. ISBN 9780702074486. info
  • Studijní materiály v IS pod kódem předmětu
  • NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010. 96 pp. ISSN 1801-6103. URL info
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
    recommended literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy
  • Farmakologie. Edited by Jan Švihovec - Jan Bultas - Pavel Anzenbacher - Jaroslav Chládek - J. 1. vydání. Praha: Grada Publishing, 2018. xix, 962. ISBN 9788024755588. info
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. info
    not specified
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
Teaching methods
Practicals, the teaching process of include theoretical setting up as well as practical training of knowledge and skills stated in Syllabus. Included are also individual work with specific pharmacological softwares and homeworks on the selected topics, presented and discussed afterward in class.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 2 written tests: 1) on drug prescription - 1 individually prepared preparation and 1 ready-made preparation (assessed individually by the teacher), 2) the multiple-choice test on knowledge of topics taught. A minimum of 9 points is required to pass the test.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021.
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