aVLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2021
Extent and Intensity
2/0/0. 7 credit(s). Type of Completion: zk (examination).
Taught online.
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Monika Šudáková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: Monika Šudáková
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable
Tue 14:00–15:50 B11/114
Prerequisites (in Czech)
aVLBI0222p Medical Biology II - lect. && aVLBF011p Biophysics -lect. && aVLBC0321s Biochemistry I - sem. && aVLBC0321c Biochemistry I - pract. && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL • The integration of intermediary metabolism at the tissue and organ level (after the meal, during starvation, stress, obesity, diabetes). • The metabolic functions of the liver. Metabolism of main nutrients. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron and copper. • Biotransformation of xenobiotics. Two phases of biotransformation, typical reactions, cytochrome P450. Metabolism of ethanol. Water and Na+, K+ ions balance, osmolality and volume of ECF, regulation, disorders. • Transport of O2 and CO2. Metabolic pathways producing/consuming H+ ions.Buffer bases of blood, blood plasma, ICF, the parameters of acid-base status. • Normal renal functions. Glomerular filtration. Tubular resorption and secretion. • Steroid and thyroid hormones – biosynthesis, secretion, and effects. • Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors. • Metabolism of nervous tissue. Neuro-secretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors. • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine. Hormones involved in their metabolism. • The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation. • The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis. • Biochemistry of blood cells. Molecular principles of immunochemistry.
Literature
    required literature
  • RODWELL, Victor W., David A. BENDER and Kathleen M. BOTHAM. Harper's illustrated biochemistry. 30th ed. New York: Mc Graw- Hill, 2015. xii, 817. ISBN 9781259252860. info
  • Lecture files including lectures notes available in IS
  • KOOLMAN, Jan and Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
    recommended literature
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018. 482 pp. ISBN 978-1-929007-63-9. info
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013. ix, 1014. ISBN 9781451100037. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016. xvi, 718. ISBN 9789385999741. info
Teaching methods
Teaching form are online lectures. Supplementary subjects are seminars and practicals
Assessment methods
Student must have course-unit credit of seminar and practicals in the day of exam. • The examination has only an oral part. The official list of examination questions will be published in the Study materials of aVLBC0422p. Three questions will be randomly selected from the three parts of the list. There will be no preparation time before the oral exam. Students are supposed to summarize the substantial and relevant issues. Examiners may ask additional questions. If appropriate, students may use paper and a pen. Exams will take place in the seminar rooms of the Department of Biochemistry in the usual contact mode.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020.
  • Enrolment Statistics (recent)
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