aVLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
doc. RNDr. Jiří Dostál, CSc. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Mon 19. 2. to Fri 5. 4. Fri 8:00–9:50 B11/114, Fri 19. 4. to Fri 31. 5. Fri 8:00–9:50 B11/114; and Fri 12. 4. 8:00–9:50 B11/234
Prerequisites (in Czech)
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic of individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
After completing the course, the student will be able to:
- explain the interrelationships between the metabolism of nutrients in different states of the organism.
- describe the metabolic characteristics of the main organs and tissues and the main disorders, and discuss their connection with diseases.
- explain the principles of metabolism regulation at all levels.
- understand the principles of maintaining homeostasis in the organism and acid-base balance, including solving model situations.
- discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
  • Blood plasma lipids. Metabolism of lipoproteins.
  • Overview of nutrient metabolism in different states.
  • Metabolic functions of liver. Catabolism of heme. Biochemical tests for liver diseases.
  • Metabolism of iron and copper. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and Na+, K+ ions balance, osmolality and volume of ECF.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases. Parameters of acid-base status.
  • Biochemical functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • General mechanisms of action of signal molecules. Hormone receptors.
  • Steroid and thyroid hormones.
  • Nervous tissue. Cerebrospinal fluid. Neurosecretion. Neurotransmitters and their receptors.
  • Endothelial cells. Blood-coagulation cascade, inhibition of clotting. Fibrinolysis.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Bone tissue. Articular cartilage and skin.
  • Biochemistry of blood cells. Major proteins of blood plasma.
    required literature
  • RODWELL, Victor W., David A. BENDER and Kathleen M. BOTHAM. Harper's illustrated biochemistry. 30th ed. New York: Mc Graw- Hill, 2015, xii, 817. ISBN 9781259252860. info
  • Study materials for the course Biochemistry II in IS MUNI.
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 pp. ISBN 978-1-929007-63-9. info
  • KOOLMAN, Jan and Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016, xvi, 718. ISBN 9789385999741. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
Teaching methods
Assessment methods
Oral exam. The student will randomly draw two questions from Biochemistry I and two questions from Biochemistry II. The student answers without preparation.
Language of instruction
Further comments (probably available only in Czech)
Information on completion of the course: Admission to the exam is conditioned by obtaining a credit of the courses: aVLBC0422s, aVLBC0422c, and aVLBC0422t.
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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Teacher's information
The basic concepts and topics covered in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/spring2024/aVLBC0422p