aVLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: prof. RNDr. Eva Táborská, CSc.
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Fri 8:00–9:50 B11/114
Prerequisites (in Czech)
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand biochemical processes characteristic of individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. It is also an introduction to clinical biochemistry.
Learning outcomes
The student is able:
- to explain the ways of obtaining biological material for biochemical analysis and is familiar with the rules of manipulation.
- to describe physiological values of the most important biochemical parameters.
- to interpret the results of biochemical analyzes, discusses the significance of the findings.
- to understand the principles of the most important biochemical-analytical methodologies.
- to be oriented in basic laboratory manipulations.
  • Plasma lipids. Lipoprotein metabolism.
  • Nutrient metabolism in different conditions.
  • Biochemical functions of the liver. Heme catabolism.
  • Iron and copper metabolism. Biotransformation of xenobiotics. Ethanol metabolism.
  • Homeostasis of water, Na + and K  + ions. Regulation of osmolality and volemia.
  • Acid-base balance. Transport O  2 and CO 2 through blood. Buffer bases.
  • Biochemical functions of the kidneys. Filtration functions. Tubular resorption and secretion.
  • Steroid and thyroid hormones.
  • Membrane and intracellular receptors. Nervous tissue metabolism. Neurotransmitters, synapses.
  • Metabolism of calcium, magnesium, phosphates, fluorine and iodine.
  • Vascular endothelium. Hemocoagulation, fibrinolysis.
  • Biochemistry of blood elements. The most important blood plasma proteins.
  • Extracellular matrix. Connective tissue metabolism.
    required literature
  • RODWELL, Victor W., David A. BENDER and Kathleen M. BOTHAM. Harper's illustrated biochemistry. 30th ed. New York: Mc Graw- Hill, 2015. xii, 817. ISBN 9781259252860. info
  • Supplementary materials: https://is.muni.cz/auth/el/med/jaro2022/aVLBC0422s/um/
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013. ix, 1014. ISBN 9781451100037. info
  • BORON, Walter F. and Emile L. BOULPAEP. Medical physiology. Third edition. Philadelphia: Elsevier, 2017. xii, 1297. ISBN 9781455743773. info
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018. 482 pp. ISBN 978-1-929007-63-9. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016. xvi, 718. ISBN 9789385999741. info
  • KOOLMAN, Jan and Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
Teaching methods
Assessment methods
Oral exam - students will draw two questions from Biochemistry I and two questions from Biochemistry II.
Language of instruction
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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Teacher's information
The basic concepts and topics covered in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021.
  • Enrolment Statistics (recent)
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