aVLPF0521c Pathophysiology I - practice

Faculty of Medicine
autumn 2022
Extent and Intensity
0/3/0. 2 credit(s). Type of Completion: z (credit).
Taught in person.
Teacher(s)
MUDr. Vendula Bartáková, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
MUDr. Jaromír Gumulec, Ph.D. (seminar tutor)
Mgr. Katarína Chalásová, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
Mgr. Andrea Knight, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
MUDr. Stanislav Matoušek, Ph.D. (seminar tutor)
MUDr. Petr Müller, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
Dipl. Ing. Martin Piskáček, Dr. rer. nat. (seminar tutor)
Mgr. Jana Šístková, Ph.D. (seminar tutor)
MUDr. Michal Šitina, Ph.D., M.Sc. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Věra Ježková (assistant)
Mgr. Šárka Lakomá (assistant)
Mgr. Lucie Válková, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Timetable of Seminar Groups
aVLPF0521c/30: Thu 10:00–12:30 B11/327, J. Máchal
aVLPF0521c/31: Tue 10:00–12:30 B11/327
aVLPF0521c/32: Thu 10:00–12:30 B11/327, J. Máchal
aVLPF0521c/33: Mon 13:00–15:30 B11/327, J. Máchal
aVLPF0521c/34: Mon 13:00–15:30 B11/327, J. Máchal
aVLPF0521c/35: Thu 10:00–12:30 B11/327, J. Máchal
aVLPF0521c/36: Tue 10:00–12:30 B11/327
aVLPF0521c/37: Wed 13:00–15:30 B11/327
Prerequisites
aVLFY0422c Physiology II - practice && aVLFY0422s Physiology II - seminar && aVLBC0422c Biochemistry II - practice && aVLBC0422s Biochemistry II - seminar && ( VLLM0421c Med.Microbiol. || aVLLM0421c Med.Microbiol. I - prac. ) && ( aVLFY0422p Physiology II - lecture || aVLBC0422p Biochemistry II - lecture )&& aVLHE0322c Histology and Embryology II -p && aVLAN0222c Anatomy II dis. && aVLAN0222s Anatomy II s
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The student will be trained for assuming this knowledge and skills:
Atherosclerosis.
Essential hypertension (tutorial), resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise.
Angiology, pulse wave, LI. Principles and demonstration of peripheral blood flow examination using ultrasonography.
Principles of ECG analysis, demonstration of selected pathological ECG patterns
Health and disease, theory of normality, system regulation Acute radiation syndrome. Presentation of the experiment.
Hemocoagulation disorders.
Regulation of haematocrit and pathophysiology of anaemia.
Pathophysiology of respiratory disorders - introduction
Obstructive and restrictive disease. Spirometry
Pathophysiology of ventilation disorders and pulmonary gas exchange.
Pathophysiological principles of oxygenotherapy and mechanical ventilation.
Genetic susceptibility to disease – monogenic vs. complex diseases. Pharmacogenetics.
Cell cycle, oncogenes and suppressor genes, cancer development.
Statistical analysis of experiments (introduction).
Learning outcomes
: Student applies the basic knowledge of biostatistics to explain the structure of reference intervals
: Student will describe the influence of ionizing radiation on the body at the level of molecular, cellular, tissue, and they justify the time dynamics of the system
: Student will describe changes in blood cell counts dynamics in the acute radiation disease
: Student makes a distinction between deterministic and stochastic effects of ionizing radiation and their practical implications
: Student will explain the principle of ultrasound and dopplerometric examination of the blood vessels, the underlying pathology of peripheral vasculature (venous valvular insufficiency, ischemia, short circuits, and steal syndromes)
: Student interprets the continuous ECG monitoring in experimental animals for several pathological conditions
: Student distinguishes ECG records most commonly occurring arrhythmias (sinus arrhythmia, SVES, atrial fibrillation, atrial flutter, AVRT, AV blockade blockade, ventricular tachycardia, torsades de pointes, ventricular fibrillation)
: Student demonstrates the basic static and dynamic parameters surveyed during the spirometric examination and their relationship to pulmonary diseased
: Student will describe the development of renal ischemia in experimental animal model
: Student will explain the determination of the glomerular filtration rate, depending on the curve of concentration of inulin excretion by the kidneys, while discussing the use of clearance of other substances (creatinine, PAH)
: Student demonstrates the emergence of renovascular hypertension in the Goldblatt´s model, renal artery stenosis, the difference between unilateral and bilateral stenosis, the role of the RAAS and the expansion of the volume due to hypertension diagnosis
Syllabus
  • Atherosclerosis.
  • Essential hypertension (tutorial), resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise.
  • Angiology, pulse wave, LI. Principles and demonstration of peripheral blood flow examination using ultrasonography.
  • Principles of ECG analysis, demonstration of selected pathological ECG patterns
  • Health and disease, theory of normality, system regulation Acute radiation syndrome. Presentation of the experiment.
  • Hemocoagulation disorders.
  • Regulation of haematocrit and pathophysiology of anaemia.
  • Pathophysiology of respiratory disorders - introduction
  • Obstructive and restrictive disease. Spirometry
  • Pathophysiology of ventilation disorders and pulmonary gas exchange.
  • Pathophysiological principles of oxygenotherapy and mechanical ventilation.
  • Genetic susceptibility to disease – monogenic vs. complex diseases. Pharmacogenetics.
  • Cell cycle, oncogenes and suppressor genes, cancer development.
  • Statistical analysis of experiments (introduction). Teachers: Mon – As. MUDr. Michal Jurajda PhD.
  • Tue – doc. RNDr. Monika Goldbergová-Pávková, PhD.; As. MUDr. Kamil Ďuriš, PhD.
  • Wed – As. MUDr. Jaromír Gumulec, PhD., as. RNDr. Michal Masařík, PhD.
  • Thu – As. MUDr. Michal Jurajda PhD.; As. MUDr. Jan Máchal, PhD.
Literature
Teaching methods
Seminars, practical exercises in labs, discussion of the given topics, video with comments. Practical training is complemented by a comprehensive range of simulation teaching methods on virtual patients.
Assessment methods
Practicals are compulsory. The only permitted reason for not attending is a student's sick leave. Students can - with the tutor's approval - substitute the particular practice in a given week with another group in case he/she has a justifiable reason for it. Students' participation in the practicals throughout the term is certified by a credit. Students can be given written tests or individual homework by tutor's throughout the term. Students have to be wearing lab coats during the practicals. Practicals are compulsory. The only permitted reason for not attending is a student's sick leave. Students can - with the tutor's approval - substitute the particular practice in a given week with another group in case he/she has a justifiable reason for it. Students' participation in the practicals throughout the term is certified by a credit. Students can be given written tests or individual homework by tutor's throughout the term. Students have to be wearing lab coats during the practicals.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Studenti opakující 3. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021.
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