BLLC0111p Medical Chemistry-lecture

Faculty of Medicine
autumn 2018
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Ing. Martina Čarnecká, Ph.D. (assistant)
Mgr. Martina Drabinová (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
PharmDr. Katarína Kostolanská (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Lenka Nerudová (assistant)
Mgr. Lucie Novotná (assistant)
Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Anna Pleskačová, Ph.D. (assistant)
Mgr. Roman Sándor (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Contact Person: Lenka Nerudová
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable
Mon 10:00–11:40 B11/327
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students have knowledge that is necessary for understanding of chemical principles applied in further study subjects, especially in biochemistry.He/she understand solution properties and basic physico-chemical laws. Describes the properties of elements and inorganic compounds important for medicine, nutrition and toxicology. Discuses the structure of compounds and reactions taking part in metabolism and organic compounds that have importance in toxicology.
Learning outcomes
Students will be able to understand basics of general, inorganic and organic chemistry to the extent necessary for the further study of biochemistry.
They will be able to apply general physicochemical laws to processes in living organisms.
They will be able to describe the chemical properties of the most important biogenic elements and essential compounds of importance in medicine, nutrition and toxicology. They will be able to describe and discuss the properties and reactions of organic and bioorganic compounds important for the understanding of biochemical processes
Syllabus
  • Chemical reactions, kinetics, chemical equilibrium. The driving force of chemical reactions, free Gibbs energy.
  • Solutions of substances. Dissociation of electrolytes, the equilibria in electrolyte solutions.Precipitation reactions.
  • Protolytic reactions: acids and bases, pH values, hydrolysis of salts, buffers.
  • Oxidation-reduction reactions, redox potentials, the e.m. force of a voltaic cell and the relation to the reaction free energy change.
  • Essential macroelements important for living matter, general properties of them and of some of their compounds.
  • Carbon compounds: their constitution, configuration, isomerism, and conformation. Types of organic compounds, the principals of nomenclature. Hydrocarbons, major types, structures, reactivity.
  • Derivatives of hydrocarbons: alcohols, thioalcohols, phenols, carbonyl compounds, and carboxylic acids.
  • Substituted carboxylic acids and derivatives of the acids (esters, amides, anhydrides, halides).
  • Amines and the other derivatives of hydrocarbons.
  • Heterocyclic compounds and biochemically important derivatives. Alkaloids.
  • Structures and properties of monosaccharides. Simple sugar derivatives. Oligosaccharides, polysaccharides.
  • Heteroglycosides. Nucleosides, nucleotides, structures of nucleic acids.
  • Fatty acids and alcohols in lipids. Triacylglycerols and waxes. Phospholipids and glycolipids.
  • Icosanoids. Isoprenoids. Steroids, structures of representative compounds.
  • Standard and other alpha-amino acids, structures and common properties, polarity. Peptides, some groups of peptides exhibiting biological activity.
  • Proteins, main features of the structure of globular, fibrous, and membrane proteins. Glycoproteins. Haemoproteins, haem and other tetrapyrrols.
Literature
Teaching methods
Teaching form are lectures. Supplementary subjects are seminars and practicals (VSLC011c and VSLC011c).
Assessment methods
The examination has two parts. First part is a simple test on computer, the second part is oral. test includes 25 basal questions from all topics, incliding calculations of concentration, pH and osmolarity. Sample test will be available till the end of october on IS. For continuation with oral examination is required at least 13 correct answers.Oral examination has 3 questions. Student must have course-unit credit of seminar and practicals in the day of exam. List of examination questions and other instruction you can find in the section Study materials.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2019, autumn 2020.
  • Enrolment Statistics (autumn 2018, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2018/BLLC0111p