aVLPF0622c Pathological Physiology II - practice

Faculty of Medicine
spring 2019
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
MUDr. Vendula Bartáková, Ph.D. (seminar tutor)
prof. MUDr. Julie Dobrovolná, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
doc. MUDr. Jaromír Gumulec, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
Mgr. Andrea Knight, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
doc. RNDr. Sabina Ševčíková, Ph.D. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLPF0622c/30: Wed 13:00–15:30 A18/112
aVLPF0622c/31: Thu 13:00–15:30 A18/112
aVLPF0622c/32: Thu 13:00–15:30 A18/112
aVLPF0622c/33: Tue 13:00–15:30 A18/112
aVLPF0622c/34: Tue 13:00–15:30 A18/112
aVLPF0622c/35: Tue 10:00–12:30 A18/112
aVLPF0622c/36: Wed 13:00–15:30 A18/112
aVLPF0521c Pathol. physiology I - pract. && aVLBC0422p Biochemistry II - lect. && aVLFY0422p Physiology II - lecture
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about pathological states and experimental work. Students will also acquire practical skills necessary for their subsequent(future) study and work.
Learning outcomes
Student will explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
Student will explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
Student demonstrates the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
Student shall identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
Student demonstrates the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
Student demonstrates onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
Student describes etiopathogenesis of venous thrombosis using data from experimental animal model;
Student will explain the importance and principles of DNA d iagnostics to detect I/D polymorphism using PCR methodology ACE
  • Exp. induced peptic ulcer in lab. animal, image analysis.
  • Obstructice jaundice preparation
  • Exp. induced jaundice in lab. animal
  • Patophysiology of GIT (tutorial)
  • Statistical evaluation of experiments (advanced methods), practical analysis of exp. data (using stat. software) Neuropathophysilogy (tutorial)
  • Exp. induced vein thrombosis in lab. animal
  • Overview of molecular biology exp. methods used in pathophysiology (tutorial & demonstration of selected lab. methods)
  • Genetic susceptibility to disease – monogenic vs. complex diseases (tutorial)
  • Haematology, blood transfusion (tutorial) Anaphylactic reaction, pathophysiology of circulatory shock (tutorial)
  • Skin barrier disorders (measurement of skin conductivity)
  • Exp. induced diabetes mellitus preparation
  • Exp. induced diabetes mellitus – diagnosis by glucose tolerance test
Teaching methods
practical exercises in lab, seminars
Assessment methods
Practicals are compulsory (the only permited reason for not attending is a student's sick leave). Students can be given written tests or individual home work by tutor's throughout the term. Student's participation in the practicals throughout the term is certified by a credit given upon the following conditions: (i) complete attendance, (ii) complete protocols from the exp. practicals, (iii) indicidual criteria announced by the principal tutor.
Language of instruction
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
Teacher's information
The course is also listed under the following terms Spring 2018, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (spring 2019, recent)
  • Permalink: https://is.muni.cz/course/med/spring2019/aVLPF0622c