C5850 Biophysical Chemistry

Faculty of Science
Autumn 2001
Extent and Intensity
2/0/0. 3 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
prof. RNDr. Libuše Trnková, CSc. (lecturer)
Guaranteed by
prof. RNDr. Libuše Trnková, CSc.
Chemistry Section - Faculty of Science
Prerequisites (in Czech)
Úspěšné zvládnutí základních předmětů - fyzikální chemie a biochemie Obsahově navazuje na tyto dva předměty
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
1. Strategy and Tactics of Biophysical Chemistry (basic questions and strategic approaches of biophysical chemistry, structural levels of biopolymers, the central role of CO2 and water in biological systems) 2. Some Problems of Biopolymer Space Structure (tertiary and quaternary structure of biopolymers, the stability of helical structures, hydrogen bond and disulphidic bond, hydrophobic interaction) 3. Interaction of Biological Molecules with Electromagnetic Radiation (absorption electron, fluorescence and infrared spectroscopies, optical activity, light scattering, resonance methods for the study of structure and function of biopolymers) 4. Dimension and Form of Macromolecules (electron microscopy, hydrodynamic methods, diffusion, sedimentation and centrifugation, roentgen crystallography) 5. Thermodynamics of Biological Systems (1) (specification of biological system, statistical interpretation of entropy, the role of entropy in the biological processes, production of entropy, the problem of standard state, ideal, regular and nonregular solutions, multi-component systems, dissipative structures) 6. Thermodynamics of Biological Systems (2) (some problems of thermodynamics of biological systems, formalism of nonequilibrium phenological thermodynamics, energetics of evolution and regeneration processes) 7. Behaviour of Macromolecules in Solution (statistical interpretation of polymer solutions, Huggins-Flory conception, dialyse equilibrium, osmotic pressure of the polymer component/ Donnan, Scatchard/, formation of random coil) 8. Polyelectrolytes (theory of PEL at the limit concentrations, distribution of counterions, expansion of polyions, thermodynamic, transport and electrical behaviour of PEL, models of PEL) 9. Kinetics of Biological Systems (kinetic processes with more substrates and with more intermediates, catalysis, enzymatic reactions and its regulation, biological clocks) 10. Polarography and Voltammetry of Biological Molecules (usage of polarographic and voltammetric technics for the research of electrochemical behaviour of proteins, nucleic acids and its components, the analysis of molecules of the farmaceutic significance) REFERENCES: 1)Ch.R.Cantor, P.R.Schimmel: Biophysical Chemistry, Vol.1, 2, 3, V. H. Freeman and Com., 11th ed., New York, 1999 2)M. Kodíček, V. Karpenko: Biofyzikální chemie, Academia, Praha 2000 3)H. Eisenberg: Biological Macromolecules and Polyelectrolytes in Solutions, Clarendon Press, Oxford 1976 4)Z. Vodrážka: Fyzikální chemie pro biologické vědy, Academia, Praha 1982 5)K. Malík et al.: Biological Electron Transport Processes, Academia, Praha 1990 6)H. Morawetz: Chování makromolekul v roztoku, Academia, Praha 1971 7)G. Dryhurst: Electrochemistry of Biological Molecules, Academic Press, New York 1977 ( Libuše Trnková)
  • Strategy and Tactics of Biophysical Chemistry Some Problems of Biopolymer Spacial Structure Interaction of Biological Molecules with Electromagnetic Radiation Dimension and Form of Macromolecules Thermodynamics of Biological Systems Statistical Interpretation of Polymer Solution Behaviour of Macromolecules in Solution Polyelectrolytes Kinetics of Biological Systems Polarography and Voltammetry of Biological Molecules Electron Transfer in Biological System
Assessment methods (in Czech)
typové příklady probírány v průběhu přednášek závěrečná zkouška nebo koloqium - ústní forma
Language of instruction
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 1999, Spring 2011 - only for the accreditation, Autumn 2000, Autumn 2002, Spring 2009, Spring 2010, Spring 2011, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020.
  • Enrolment Statistics (Autumn 2001, recent)
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